Description

2',3'-Lyxoanhydrothymidine 5'-Triphosphate is a chemically modified nucleotide triphosphate analog, a key building block for advanced biochemical research and development. This compound is essential for studying nucleic acid metabolism, enzyme mechanisms, and for the development of novel therapeutic agents and diagnostic tools. It is primarily utilized by research institutions, pharmaceutical R&D departments, and biotechnology companies focused on antiviral drug discovery, molecular biology, and enzymology.

Application

• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies, particularly for DNA polymerases and reverse transcriptases to investigate reaction mechanisms and fidelity.
• Antiviral Drug Development: Serves as a critical precursor or analog in the synthesis and evaluation of nucleoside reverse transcriptase inhibitors (NRTIs) for HIV and other viral targets.
• Molecular Biology Tools: Employed in the synthesis of modified oligonucleotides for probing nucleic acid structure, function, and for developing advanced PCR or sequencing techniques.
• Enzymology Studies: Acts as a tool compound to study the kinetics and specificity of kinases, nucleotidyltransferases, and other ATP-utilizing enzymes.
• Diagnostic Assay Development: Used in the formulation of specialized kits and assays for detecting specific enzymatic activities or for high-throughput screening (HTS) campaigns.

Basic Information

Product Name	2',3'-Lyxoanhydrothymidine 5'-Triphosphate
CAS No.	125676-73-5
Molecular Formula	C10H16N3O13P3
Molecular Weight	503.16 g/mol
Synonyms	2',3'-Didehydro-2',3'-dideoxythymidine 5'-triphosphate; d4TTP; Stavudine triphosphate; 1-((2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione 5'-(trihydrogen triphosphate); Lyxo-Anhydro-Thymidine Triphosphate; 2',3'-Unsaturated Thymidine 5'-Triphosphate
EINECS	Contact for details

Quality Control

Our 2',3'-Lyxoanhydrothymidine 5'-Triphosphate is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing including HPLC for purity and identity confirmation (NMR, MS) to ensure it meets the high standards required for sensitive research applications. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting purity, assay, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, it is recommended to store desiccated under an inert atmosphere. Allow the vial to warm to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Assay	≥ 90% (by UV spectrophotometry)
Water Content (KF)	≤ 3.0%
Solubility	Soluble in water, buffer solutions

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.