Description

Mofarotene is a synthetic retinoid compound with significant research and development applications. Its primary value lies in its potent biological activity, which makes it a critical compound for advanced pharmaceutical studies. This product is essential for researchers and developers in the pharmaceutical and biotechnology sectors, particularly those focused on oncology, dermatology, and novel therapeutic agent discovery.

Application

• Pharmaceutical R&D: A key intermediate or active compound in the research and development of novel retinoid-based therapeutics.
• Oncology Research: Investigated for its potential anti-proliferative and differentiating effects in various cancer cell studies.
• Dermatology Research: Used in studies targeting skin disorders, leveraging retinoid pathways for potential treatment development.
• Biochemical Research: Serves as a reference standard or probe in studies of nuclear receptor (RAR/RXR) signaling and gene regulation.
• Preclinical Studies: Utilized in animal models to evaluate pharmacokinetics, efficacy, and safety profiles of retinoid analogs.

Basic Information

Product Name	Mofarotene
CAS No.	125533-88-2
Molecular Formula	C23H28O3
Molecular Weight	352.47 g/mol
Synonyms	4-[(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)carbamoyl]benzoic Acid; Ro 40-8757; Mofarotene (Ro 40-8757); Ro-40-8757; Ro 408757; Benzoic acid, 4-[[(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)amino]carbonyl]-; AGN-195183
EINECS	Contact for details

Quality Control

Our Mofarotene is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We support compliance with relevant guidelines for research materials, and specifications can be aligned with client requirements for advanced development phases.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) to minimize oxidation and ensure long-term stability. Keep the container in a dry, cool, and well-ventilated area.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.