Description

4-(Methylsulfonyl)Phenyl Bis(5-(2-Bromovinyl)-2'-Deoxyuridin-5-Yl)Phosphate is a sophisticated, high-purity nucleotide analog derivative designed for advanced research and development. This compound is critical for scientists working on the cutting edge of antiviral and anticancer therapeutic strategies, particularly in the development of prodrugs and targeted molecular probes. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and biotechnology companies specializing in nucleoside chemistry and medicinal chemistry.

Application

• Antiviral Drug Research: Serves as a key intermediate or active pharmaceutical ingredient (API) precursor in the development of novel antiviral agents.
• Oncology Research: Investigated for its potential in creating targeted anticancer prodrugs, especially those activated in tumor microenvironments.
• Biochemical Probes: Used in the synthesis of labeled nucleotide analogs for studying enzyme mechanisms, such as those involving polymerases or kinases.
• Medicinal Chemistry: A valuable building block for structure-activity relationship (SAR) studies to optimize the potency and selectivity of nucleoside-based therapeutics.
• Prodrug Development: The bis-phosphate moiety is engineered for enhanced cellular uptake and subsequent enzymatic activation, making it a candidate for prodrug strategies.
• Radiopharmaceuticals: Potential precursor for the development of diagnostic or therapeutic radiopharmaceuticals due to the bromine atom, which can be used for radiohalogenation.

Basic Information

Product Name	4-(Methylsulfonyl)Phenyl Bis(5-(2-Bromovinyl)-2'-Deoxyuridin-5-Yl)Phosphate
CAS No.	125440-31-5
Molecular Formula	C30H31Br2N4O15P S
Molecular Weight	942.45 g/mol
Synonyms	4-(Methylsulfonyl)phenyl bis[5-(2-bromovinyl)-2'-deoxyuridin-5'-yl] phosphate; 5'-[4-(Methylsulfonyl)phenyl] bis[5-(2-bromovinyl)-2'-deoxyuridine] 5'-phosphate; BVDU Bisphosphate Prodrug; (E)-5-(2-Bromovinyl)-2'-deoxyuridine 5'-(4-methylsulfonylphenyl) bisphosphate; Nucleoside Prodrug Intermediate; 125440-31-5; BVdUMP Bis(Methylsulfonylphenyl) Ester
EINECS	Contact for details

Quality Control

Our 4-(Methylsulfonyl)Phenyl Bis(5-(2-Bromovinyl)-2'-Deoxyuridin-5-Yl)Phosphate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the exacting standards required for pharmaceutical research. Certificates of Analysis (COA) with full traceability are provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed under inert atmosphere (e.g., argon or nitrogen) when not in use to prevent degradation. For long-term storage, consider storing at -20°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.