Description

Adenosine,2-Amino-3'-Deoxy-3'-Fluoro- (9Ci) is a chemically modified nucleoside analog, specifically a fluorinated derivative of adenosine, which is a critical building block in nucleic acid research and pharmaceutical development. This compound matters because the strategic introduction of fluorine at the 3'-position and an amino group at the 2'-position significantly alters its biological activity and metabolic stability, making it a valuable tool for probing enzyme mechanisms and designing novel therapeutics. It is primarily needed by research institutions and pharmaceutical companies engaged in antiviral drug discovery, oncology research, and the synthesis of modified oligonucleotides for diagnostic and therapeutic applications.

Application

• Antiviral and Anticancer Nucleoside Analog Synthesis: Serves as a key synthetic intermediate for developing novel prodrugs targeting viral polymerases and cellular enzymes involved in cancer proliferation.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies to investigate the structure and function of kinases, polymerases, and other adenosine-binding proteins.
• Oligonucleotide Chemistry: Incorporated into synthetic oligonucleotides to enhance nuclease resistance, alter binding affinity, or introduce specific labels for diagnostic probes.
• Medicinal Chemistry & SAR Studies: A crucial compound for structure-activity relationship (SAR) studies to optimize the potency and selectivity of adenosine receptor ligands.
• Reference Standard: Employed as a high-purity analytical standard in quality control and method development for pharmaceutical analysis (HPLC, LC-MS).

Basic Information

Item	Detail
Product Name	Adenosine,2-Amino-3'-Deoxy-3'-Fluoro- (9Ci)
CAS No.	125391-75-5
Molecular Formula	C10H13FN6O3
Molecular Weight	284.25 g/mol
Synonyms	2-Amino-3'-deoxy-3'-fluoroadenosine; 3'-Fluoro-2-aminoadenosine; 3'-Deoxy-3'-fluoro-2-aminoadenosine; 2-Amino-9-(3-deoxy-3-fluoro-β-D-ribofuranosyl)adenine; 9-(3-Deoxy-3-fluoro-β-D-ribofuranosyl)-2-aminoadenine; 2-Aminoadenosine, 3'-deoxy-3'-fluoro- derivative; 3'-F-2-NH2-Ado
EINECS	Contact for details

Quality Control

Every batch of Adenosine,2-Amino-3'-Deoxy-3'-Fluoro- (9Ci) is manufactured under strict quality management systems. We provide comprehensive analytical documentation to ensure product integrity for critical research and development. Our standard quality commitment includes rigorous testing via HPLC, NMR, and MS to confirm identity, purity, and the absence of critical impurities. A Certificate of Analysis (COA) detailing batch-specific results is available for every shipment upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container should be kept in a desiccated environment. For long-term storage, consider storing under an inert atmosphere to ensure maximum stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.