Description

4-(Chlorocarbonyl)-3,5-Difluoroanisole, also known as 4-(Chloroformyl)-3,5-Difluoroanisole or 2,6-Difluoro-p-Anisoyl Chloride, is a high-value, multi-functional aromatic acid chloride intermediate. This compound is critical for introducing the 2,6-difluoro-4-methoxybenzoyl moiety into complex molecules, enabling precise structural modifications. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for synthesizing advanced active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in fluorinated drug candidates targeting CNS disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Used in creating advanced herbicides, fungicides, and insecticides where the difluoroanisole structure contributes to enhanced biological activity and environmental stability.
• Liquid Crystal Materials: Serves as a precursor in the production of fluorinated liquid crystals for high-performance displays (LCDs).
• Polymer Chemistry: Acts as a monomer or modifying agent for engineering plastics and high-performance polymers, imparting specific thermal and chemical resistance properties.
• Organic Synthesis & Research: A versatile reagent for peptide coupling (as an activated acid) and for constructing complex fluorinated aromatic systems in academic and industrial research settings.
• Dye and Pigment Intermediate: Employed in the synthesis of specialized fluorinated dyes and pigments for niche applications.

Basic Information

Product Name	4-(Chlorocarbonyl)-3,5-Difluoroanisole
CAS No.	125369-56-4
Molecular Formula	C9H5ClF2O2
Molecular Weight	218.58 g/mol
Synonyms	4-(Chloroformyl)-3,5-Difluoroanisole; 2,6-Difluoro-p-Anisoyl Chloride; 3,5-Difluoro-4-methoxybenzoyl chloride; 4-Methoxy-3,5-difluorobenzoyl chloride; 2,6-Difluoro-4-methoxybenzoyl chloride; p-Anisoyl chloride, 2,6-difluoro-; Benzoyl chloride, 3,5-difluoro-4-methoxy-
EINECS	Contact for details

Quality Control

Every batch of 4-(Chlorocarbonyl)-3,5-Difluoroanisole is manufactured and tested under strict quality management systems. We ensure high purity and consistency through comprehensive analytical controls including HPLC, GC, NMR, and titration methods. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature and reactivity as an acid chloride, it should be kept under an inert atmosphere (e.g., nitrogen or argon) for long-term storage. Recommended storage temperature is 2-8°C for optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.