Description

3'-Deoxy-3'-Fluoro-5-Methyluridine is a fluorinated nucleoside analog, a key building block in medicinal chemistry and pharmaceutical research. This modified nucleoside is valued for its role in the synthesis of novel antiviral and anticancer agents, where its structural modifications can enhance metabolic stability and biological activity. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers engaged in the development of nucleoside-based therapeutics.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel antiviral drugs, particularly those targeting viral polymerases.
• Anticancer Agent Research: Used in the development and study of nucleoside analogs designed to inhibit cancer cell proliferation.
• Biochemical Research: Serves as a tool compound for studying enzyme mechanisms, such as those of thymidine kinase and other nucleoside-metabolizing enzymes.
• Prodrug Development: Employed in the design of prodrugs to improve the bioavailability and targeting of therapeutic nucleosides.
• Labeled Compound Synthesis: Acts as a starting material for the preparation of isotopically labeled (e.g., tritiated, carbon-14) compounds for metabolic and pharmacokinetic studies.

Basic Information

Product Name	3'-Deoxy-3'-Fluoro-5-Methyluridine
CAS No.	125217-37-0
Molecular Formula	C10H13FN2O5
Molecular Weight	260.22 g/mol
Synonyms	3'-Fluoro-3'-deoxy-5-methyluridine; 5-Methyl-3'-deoxy-3'-fluorouridine; 3'-F-3'-d5MU; 1-((2R,4S,5R)-4-Fluoro-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione; 3'-Deoxy-3'-fluorothymidine (common misnomer, structurally related); FLT (abbreviation); Fd5MU; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our 3'-Deoxy-3'-Fluoro-5-Methyluridine is produced under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and moisture. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to ensure traceability and compliance with your research or cGMP starting material requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.