Description

5-Amino-3-(2,3,5-Tri-o-Acetyl-β-Ribofuranosyl)Thiazolo(4,5-D)Pyrimidine-2,7-Dione is a sophisticated nucleoside analogue building block of significant interest in advanced pharmaceutical research and development. This compound matters as a key synthetic intermediate for the creation of novel antiviral and anticancer agents, particularly those targeting viral polymerases and cellular enzymes involved in nucleotide metabolism. It is primarily needed by research institutions, biotechnology firms, and pharmaceutical companies engaged in the discovery and synthesis of next-generation therapeutic nucleosides and nucleotides.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the synthesis of novel nucleoside-based antiviral drugs.
• Anticancer Agent Research: Used in the development and screening of potential chemotherapeutic compounds that interfere with DNA/RNA synthesis.
• Biochemical Research: Employed as a substrate or inhibitor in enzymatic studies related to nucleotide metabolism and polymerase activity.
• Prodrug Synthesis: Utilized for constructing prodrug forms of nucleoside analogues to enhance bioavailability and targeting.
• Chemical Biology Probes: Acts as a building block for creating labeled or modified nucleosides used to study biological processes.
• Reference Standard: Provides a high-purity standard for analytical method development and quality control in API manufacturing.

Basic Information

Item	Detail
Product Name	5-Amino-3-(2,3,5-Tri-o-Acetyl-β-Ribofuranosyl)Thiazolo(4,5-D)Pyrimidine-2,7-Dione
CAS No.	124737-24-2
Molecular Formula	C16H18N4O9S
Molecular Weight	442.40 g/mol
Synonyms	5-Amino-3-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)thiazolo[4,5-d]pyrimidine-2,7(3H,6H)-dione; 2,7-Dioxo-2,3,6,7-tetrahydro-5-amino-3-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)thiazolo[4,5-d]pyrimidine; Acetylated Thiazolopyrimidine Nucleoside; 124737-24-2; Thiazolo[4,5-d]pyrimidine nucleoside derivative
EINECS	Contact for details

Quality Control

Our 5-Amino-3-(2,3,5-Tri-o-Acetyl-β-Ribofuranosyl)Thiazolo(4,5-D)Pyrimidine-2,7-Dione is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles, generated using validated analytical methods including HPLC and NMR. We support compliance with cGMP guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a desiccated environment and handled under conditions that minimize exposure to ambient light and humidity to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.