Description

(-)-(S)-Benproperinium Dihydrogen Phosphate is a high-purity, single-enantiomer active pharmaceutical ingredient (API) and key chiral intermediate. This compound is valued for its specific stereochemistry, which is critical for targeted biological activity and efficacy in advanced pharmaceutical formulations. It is essential for research institutions and manufacturers developing enantiomerically pure therapeutics, particularly in the respiratory and central nervous system (CNS) sectors.

Application

• Pharmaceutical Active Ingredient (API): Primary use as the active enantiomer in antitussive (cough suppressant) medications.
• Chiral Intermediate: Critical building block for the synthesis of more complex, stereospecific drug molecules.
• Pharmacological Research: Used in studies investigating the mechanism of action and receptor binding of benproperine derivatives.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical labs.
• Formulation Development: Employed in R&D for developing new dosage forms such as tablets, capsules, and syrups.

Basic Information

Product Name	(-)-(S)-Benproperinium Dihydrogen Phosphate
CAS No.	124700-67-0
Molecular Formula	C21H29NO5P
Molecular Weight	406.43 g/mol
Synonyms	(-)-S-Benproperine Phosphate; (S)-Benproperine Phosphate; L-Benproperine Phosphate; Benproperine Phosphate (S-isomer); 1-[2-(Benzylphenoxy)-1-methylethyl]piperidine phosphate (S)-form; S-(-)-1-(2-Benzylphenoxy)-2-piperidinopropane phosphate; S-Benproperine Dihydrogen Phosphate; (S)-1-[2-(Benzylphenoxy)-1-methylethyl]piperidine dihydrogen phosphate
EINECS	Contact for details

Quality Control

Our (-)-(S)-Benproperinium Dihydrogen Phosphate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets stringent specifications for pharmaceutical use. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and compliance with your research or cGMP requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.5%
Chiral Purity (Enantiomeric Excess)	≥ 99.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 1.0%; Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.