Description

(S)-Benproperine is the single enantiomer of the antitussive agent benproperine, offering a more targeted pharmacological profile. This high-purity chiral intermediate is critical for the development and production of advanced pharmaceutical formulations where stereoselectivity is paramount. It is essential for pharmaceutical R&D laboratories and manufacturers specializing in respiratory medications, enantiomerically pure APIs, and novel drug delivery systems.

Application

• Key chiral building block for the synthesis of enantiomerically pure antitussive (cough suppressant) APIs.
• Critical intermediate in pharmaceutical research for studying structure-activity relationships (SAR) of benproperine enantiomers.
• Used in the development of advanced respiratory therapeutics with potentially improved efficacy and reduced side effects.
• Reference standard for analytical method development and quality control (HPLC, Chiral Chromatography) in pharmaceutical labs.
• Starting material for process chemistry and route scouting for scalable enantioselective synthesis.
• Candidate for incorporation into novel drug delivery systems targeting specific receptor interactions.

Basic Information

Product Name	(S)-Benproperine
CAS No.	124700-66-9
Molecular Formula	C21H27NO
Molecular Weight	309.45 g/mol
Synonyms	(S)-1-[2-(2-Benzylphenoxy)-1-methylethyl]piperidine; (S)-Benproperine Phosphate Intermediate; L-Benproperine; (-)-Benproperine; (S)-α-(2-Piperidyl)-2-benzylbenzenepropanol; Benproperine S-Enantiomer; (S)-Form of Benproperine
EINECS	Contact for details

Quality Control

Our (S)-Benproperine is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including chiral purity assay and identification of impurities, to ensure it meets the high standards required for pharmaceutical development. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥98.5%
Chiral Purity (Enantiomeric Excess)	≥99.0%
Related Substances (HPLC)	Total impurities ≤1.5% Any single impurity ≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Loss on Drying	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.