Description

(+)-(R)-Benproperinium Dihydrogen Phosphate CAS NO 124678-31-5 is a high-purity, enantiomerically pure salt form of the active pharmaceutical ingredient benproperine. This specific stereoisomer is critical for ensuring targeted pharmacological activity and consistent therapeutic outcomes in advanced pharmaceutical formulations. It is primarily required by research institutions and pharmaceutical manufacturers engaged in the development and production of sophisticated antitussive (cough suppressant) medications and other specialized therapeutic agents.

Application

• Pharmaceutical Active Ingredient (API): Core component in the formulation of prescription antitussive medications.
• Clinical Research & Development: Used in preclinical and clinical studies to investigate the efficacy and safety of enantiomerically pure therapeutics.
• Reference Standard: Serves as a certified reference material (CRM) for quality control and analytical method development in pharmaceutical laboratories.
• Process Chemistry & Synthesis: Intermediate or starting material for the synthesis of more complex chiral pharmaceutical compounds.
• Formulation Development: Utilized in developing novel drug delivery systems such as controlled-release tablets, syrups, or inhalable formulations.

Basic Information

Product Name	(+)-(R)-Benproperinium Dihydrogen Phosphate
CAS No.	124678-31-5
Molecular Formula	C21H29NO5P
Molecular Weight	406.44 g/mol
Synonyms	(R)-Benproperine Phosphate; (+)-Benproperine Phosphate; (R)-(+)-1-[2-(Benzylphenoxy)-1-methylethyl]piperidine Phosphate; Benproperine Phosphate (R-enantiomer); L-Benproperine Phosphate; Dextro-Benproperine Phosphate; Pirexyl Phosphate (stereospecific); Tussafug Phosphate (stereospecific)
EINECS	Contact for details

Quality Control

Our (+)-(R)-Benproperinium Dihydrogen Phosphate is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing to ensure it meets high-purity standards suitable for pharmaceutical research and development. A detailed Certificate of Analysis (COA) providing specifications for identity, purity, enantiomeric excess, and related substances is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.0% (on anhydrous basis)
Enantiomeric Purity (Chiral HPLC)	≥99.0% (R)-enantiomer
Water (KF)	≤2.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.