Description

R-Benproperine is a high-purity pharmaceutical intermediate and active ingredient, identified by CAS NO 124678-30-4. This compound is a key chiral building block in the synthesis of advanced active pharmaceutical ingredients (APIs), valued for its specific stereochemistry and consistent quality. It is primarily required by pharmaceutical manufacturers and R&D organizations engaged in the development and production of respiratory therapeutics and other specialized medications.

Application

• Pharmaceutical Synthesis: A critical chiral intermediate in the production of benproperine and related antitussive (cough suppressant) APIs.
• Active Pharmaceutical Ingredient (API) Manufacturing: Serves as a direct precursor or building block in GMP-compliant API production lines.
• Research & Development: Used in medicinal chemistry research for developing new therapeutic agents targeting the central nervous and respiratory systems.
• Process Development & Scale-Up: Employed in optimizing synthetic routes and scaling up from laboratory to commercial production.
• Reference Standard: Utilized as an analytical standard for quality control and method validation in pharmaceutical testing laboratories.

Basic Information

Product Name	R-Benproperine
CAS No.	124678-30-4
Molecular Formula	C21H27NO
Molecular Weight	309.45 g/mol
Synonyms	(R)-Benproperine; (R)-1-[2-(2-Benzylphenoxy)-1-methylethyl]piperidine; (R)-1-[1-Methyl-2-(2-benzylphenoxy)ethyl]piperidine; R-Benproperine phosphate intermediate; Dextro-Benproperine; R-Form Benproperine; Benproperine R-Isomer; UNII-8V8W7Q7K8P (component)
EINECS	Contact for details

Quality Control

Our R-Benproperine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We support compliance with ICH Q7 guidelines and relevant pharmacopeial standards for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.5%
Optical Rotation [α]	Specific range provided on COA
Related Substances (HPLC)	Total impurities ≤1.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	<20 ppm
Loss on Drying	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.