Description

1,3-Dioxolane-4-Carbonyl Chloride, 2,2,5-Trimethyl-, (4S-Cis)- (9Ci) is a high-purity, stereochemically defined chiral building block of significant value in advanced organic synthesis. Its core value proposition lies in its role as a reactive acyl chloride derivative, enabling the efficient introduction of a protected dihydroxyacetone-like moiety into complex molecular architectures. This compound is critically needed by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, particularly those targeting complex biological pathways.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of new drug candidates, especially in antiviral, anticancer, and metabolic disease research.
• Agrochemical Synthesis: Used in the creation of advanced, stereospecific pesticides and herbicides with improved efficacy and environmental profiles.
• Asymmetric Synthesis: Serves as a crucial electrophile in stereoselective C-C and C-O bond-forming reactions to construct complex chiral centers.
• Peptide & Carbohydrate Mimetics: Facilitates the incorporation of non-natural, functionalized fragments into peptide chains or sugar analogs for biological studies.
• Material Science Research: Employed in the synthesis of specialized monomers for polymers with tailored properties.
• Process Chemistry Development: Used in route scouting and optimization for scalable manufacturing of fine chemicals.

Basic Information

Item	Details
Product Name	1,3-Dioxolane-4-Carbonyl Chloride, 2,2,5-Trimethyl-, (4S-Cis)- (9Ci)
CAS No.	124600-39-1
Molecular Formula	C8H13ClO3
Molecular Weight	192.64 g/mol
Synonyms	(4S-cis)-2,2,5-Trimethyl-1,3-dioxolane-4-carbonyl chloride; (4S,5S)-2,2,5-Trimethyl-1,3-dioxolane-4-carbonyl chloride; (S,S)-2,2,5-Trimethyl-1,3-dioxolane-4-carbonyl chloride; (4S,5S)-2,2,5-Trimethyl-[1,3]dioxolane-4-carbonyl chloride; 1,3-Dioxolane-4-carbonyl chloride, 2,2,5-trimethyl-, (4S-cis)-; (4S,5S)-2,2,5-Trimethyl-1,3-dioxolane-4-carboxylic acid chloride
EINECS	Contact for details

Quality Control

Our production of 1,3-Dioxolane-4-Carbonyl Chloride, 2,2,5-Trimethyl-, (4S-Cis)- (9Ci) adheres to stringent quality protocols suitable for advanced R&D and process development. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure consistent stereochemical integrity and chemical purity. Comprehensive Certificates of Analysis (COA) detailing identity, assay, impurity profile, and enantiomeric excess are provided to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Due to its properties as a strong acid/organic solvent, hygroscopic (moisture-sensitive), and highly volatile nature, store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry, and well-ventilated place. Recommended storage temperature is 2-8°C for long-term stability. Allow the sealed container to equilibrate to room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.