Description

1-Pyrrolidinecarboxylic Acid, 3-(Chlorocarbonyl)-, Ethyl Ester (9Ci) is a high-value, multifunctional chemical intermediate featuring both a reactive acid chloride group and a pyrrolidine scaffold. This compound matters for its versatility in facilitating complex molecular construction, particularly in the synthesis of advanced pharmaceutical agents and agrochemicals. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce chiral, nitrogen-containing motifs into target molecules.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of active pharmaceutical ingredients (APIs), especially those containing proline-like or pyrrolidine-based structures, which are common in protease inhibitors and neurological drugs.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides where the pyrrolidine ring contributes to biological activity and selectivity.
• Peptidomimetic Research: Serves as a crucial precursor in medicinal chemistry for creating peptide analogs and peptidomimetics to improve metabolic stability and bioavailability.
• Ligand and Catalyst Development: Employed in the preparation of chiral ligands and organocatalysts used in asymmetric synthesis.
• Polymer Modification: Acts as a functional monomer or cross-linking agent for introducing reactive sites and nitrogen functionalities into specialty polymers.
• Custom Synthesis & Contract Manufacturing: A valuable starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	1-Pyrrolidinecarboxylic Acid, 3-(Chlorocarbonyl)-, Ethyl Ester (9Ci)
CAS No.	124438-21-7
Molecular Formula	C8H12ClNO3
Molecular Weight	205.64 g/mol
Synonyms	Ethyl 3-(Chlorocarbonyl)pyrrolidine-1-carboxylate; 1-(Ethoxycarbonyl)-3-pyrrolidinecarbonyl Chloride; 3-(Chlorocarbonyl)-1-pyrrolidinecarboxylic Acid Ethyl Ester; 1-Carbethoxy-3-carboxypyrrolidine Chloride; Pyrrolidine-1,3-dicarboxylic Acid 1-Ethyl Ester 3-Chloride; NSC 405122; 3-Carboxy-1-pyrrolidinecarboxylic Acid Ethyl Ester Chloride
EINECS	Contact for details

Quality Control

Our 1-Pyrrolidinecarboxylic Acid, 3-(Chlorocarbonyl)-, Ethyl Ester (9Ci) is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure high purity and consistent chemical identity. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.