Description

3'-Isocyano-2',3'-Dideoxyuridine is a specialized nucleoside analog featuring an isocyano functional group at the 3' position. This compound is a critical synthetic intermediate in medicinal chemistry, enabling the development of novel antiviral and anticancer agents. It is primarily utilized by pharmaceutical R&D departments, biotechnology companies, and academic research institutions focused on nucleoside-based drug discovery and chemical biology.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of modified nucleoside prodrugs and potential antiviral therapeutics.
• Antiviral Research: Serves as a precursor in the development of novel compounds targeting viral polymerases, particularly for HIV and hepatitis viruses.
• Chemical Biology Probe: Used to create isonitrile-containing probes for studying enzyme mechanisms and biomolecular interactions via click chemistry or metal-catalyzed reactions.
• Anticancer Agent Development: Investigated as an intermediate for synthesizing nucleoside analogs that inhibit cancer cell proliferation.
• Organic Synthesis: Valuable synthon for introducing the isocyano group into complex molecular architectures for further functionalization.

Basic Information

Product Name	3'-Isocyano-2',3'-Dideoxyuridine
CAS No.	124288-72-8
Molecular Formula	C10H11N3O5
Molecular Weight	253.21 g/mol
Synonyms	3'-Isocyano-2',3'-dideoxyuridine; 2',3'-Dideoxy-3'-isocyanouridine; 1-[(2R,5S)-5-(Isocyanomethyl)oxolan-2-yl]pyrimidine-2,4-dione; 3'-Isocyano-ddU; Isocyano-dideoxyuridine; NSC 330836; Uridine, 2',3'-dideoxy-3'-isocyano-
EINECS	Contact for details

Quality Control

Our 3'-Isocyano-2',3'-Dideoxyuridine is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency, suitable for research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable to support our clients' regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions or a dry inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.