Description

5'-Tbdms-2,3'-Anhydro-2'-Deoxyuridine is a key protected nucleoside derivative, specifically engineered for advanced oligonucleotide synthesis and medicinal chemistry research. This compound serves as a critical synthetic intermediate, enabling the precise construction of modified nucleic acid sequences with enhanced stability and biological activity. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers specializing in the development of antisense oligonucleotides, siRNA, and other therapeutic nucleic acid analogs.

Application

• Synthesis of Modified Oligonucleotides: Acts as a crucial building block for introducing specific modifications into DNA/RNA strands.
• Antisense & siRNA Therapeutic Development: Used in the research and production of therapeutic agents that target gene expression.
• Medicinal Chemistry & Prodrug Design: Serves as an intermediate for creating novel nucleoside-based prodrugs and active pharmaceutical ingredients (APIs).
• Biochemical Research: Employed in studies investigating nucleic acid structure, function, and enzyme interactions.
• Labeled Nucleotide Production: A precursor for synthesizing nucleosides tagged with fluorescent or other reporter groups.
• Process Development & Scale-up: Supports optimization and manufacturing processes for nucleotide-based therapeutics.

Basic Information

Product Name	5'-Tbdms-2,3'-Anhydro-2'-Deoxyuridine
CAS No.	124288-67-1
Molecular Formula	C15H24N2O5Si
Molecular Weight	340.45 g/mol
Synonyms	2,3'-Anhydro-5'-O-(tert-butyldimethylsilyl)-2'-deoxyuridine; 5'-O-TBDMS-2,3'-anhydro-2'-deoxyuridine; 2'-Deoxy-5'-O-(tert-butyldimethylsilyl)-2,3'-anhydrouridine; 2,3'-Anhydro-2'-deoxy-5'-O-[(1,1-dimethylethyl)dimethylsilyl]uridine; 5'-tert-Butyldimethylsilyl-2,3'-anhydro-2'-deoxyuridine; TBDMS-Anhydro-dU
EINECS	Contact for details

Quality Control

Our 5'-Tbdms-2,3'-Anhydro-2'-Deoxyuridine is produced under strict quality management systems to ensure batch-to-batch consistency and high purity for research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP guidelines where applicable to support our clients' regulatory and compliance needs in pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.