Description

5'-O,N6-Bis-(4-Methoxytrityl)-Adenosine is a highly protected nucleoside derivative, a critical intermediate in the synthesis of oligonucleotides and modified nucleotides. Its value lies in providing selective protection for the adenosine molecule, enabling precise and efficient chemical transformations during solid-phase synthesis. This compound is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors, particularly those developing antisense oligonucleotides, siRNA, and other nucleic acid-based therapeutics.

Application

• Oligonucleotide Synthesis: A key protected intermediate in the automated solid-phase synthesis of DNA and RNA sequences for research and therapeutic applications.
• Antisense Drug Development: Used in the production of antisense oligonucleotides designed to target specific mRNA sequences for the treatment of genetic disorders, cancers, and viral infections.
• siRNA and miRNA Synthesis: Critical for constructing short interfering RNA (siRNA) and microRNA (miRNA) molecules used in gene silencing and functional genomics research.
• Pharmaceutical Intermediates: Serves as a high-purity building block for the synthesis of novel nucleoside-based prodrugs and antiviral agents.
• Diagnostic Probe Manufacturing: Employed in the creation of labeled nucleotide probes for diagnostic assays, including PCR and hybridization techniques.
• Bioconjugation and Labeling: The protected structure allows for further functionalization and attachment of reporter molecules (e.g., fluorophores, biotin) for tracking and detection studies.

Basic Information

Product Name	5'-O,N6-Bis-(4-Methoxytrityl)-Adenosine
CAS No.	124040-41-1
Molecular Formula	C52H49N5O6
Molecular Weight	839.98 g/mol
Synonyms	5'-O,N6-Bis(4-methoxytrityl)adenosine; N6,5'-O-Bis(4-methoxytrityl)adenosine; Adenosine, 5'-O,N6-bis(4-methoxytrityl)-; 5'-O-(4-Methoxytrityl)-N6-(4-methoxytrityl)adenosine; DMTr-protected Adenosine derivative; Bis-MTr-Adenosine; 5'-O,N6-Di(4-methoxytrityl)adenosine
EINECS	Contact for details

Quality Control

Our 5'-O,N6-Bis-(4-Methoxytrityl)-Adenosine is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. We provide comprehensive analytical data, including HPLC purity, identity confirmation by NMR and mass spectrometry, and moisture content analysis. A Certificate of Analysis (COA) detailing all specifications is supplied with each batch to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label or COA. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Keep container tightly sealed in a desiccator when not in use.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF; Slightly soluble in acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.