Description

4-Bromo-2,5-Difluorobenzoic Acid Chloride is a high-purity, reactive aromatic acid chloride derivative, serving as a critical building block in advanced organic synthesis. Its value lies in enabling the efficient introduction of a functionalized benzoic acid moiety, which is essential for constructing complex molecular architectures with precise electronic and steric properties. This intermediate is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring a difluorinated and brominated aromatic core for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides, where the halogenated aromatic system contributes to biological activity.
• Liquid Crystal & OLED Material Precursor: Serves as a starting material for synthesizing fluorinated aromatic compounds used in electronic displays and organic light-emitting diodes.
• Polymer Modification: Employed to introduce functional side chains into polymers, altering their physical properties for specialized coatings or high-performance materials.
• Cross-Coupling Reactions: The bromine atom acts as a handle for palladium-catalyzed reactions (e.g., Suzuki, Heck), allowing for further structural diversification.
• Peptide Mimetics & Bioconjugation: The acid chloride group is highly reactive with amines, making it useful for creating amide bonds in peptide-like structures or for labeling biomolecules.

Basic Information

Product Name	4-Bromo-2,5-Difluorobenzoic Acid Chloride
CAS No.	123942-09-6
Molecular Formula	C7H2BrClF2O
Molecular Weight	255.45 g/mol
Synonyms	4-Bromo-2,5-difluorobenzoyl chloride; 2,5-Difluoro-4-bromobenzoyl chloride; Benzoic acid, 4-bromo-2,5-difluoro-, chloride; 4-Bromo-2,5-difluorobenzoic acid chloride; 4-Bromo-2,5-difluorobenzoyl chloride; 4-Bromo-α,α,2,5-tetrafluorotoluene? (incorrect but sometimes searched); BDFBC (abbreviation)
EINECS	Contact for details

Quality Control

Our 4-Bromo-2,5-Difluorobenzoic Acid Chloride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via FT-IR and NMR, to ensure it meets the high standards required for sensitive synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, impurity profile, and physical characteristics is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, containers must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent hydrolysis. Keep away from strong bases, alcohols, and water.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.