Description

22,23-Dihydrobufalin is a high-purity, specialized cardiac glycoside derivative of significant interest in pharmaceutical research and development. This compound serves as a critical intermediate and reference standard for the study of cardiotonic steroids and their mechanisms of action. It is primarily utilized by research institutions, pharmaceutical companies, and contract development and manufacturing organizations (CDMOs) engaged in cardiovascular drug discovery, toxicology studies, and biochemical pathway analysis.

Application

• Pharmaceutical R&D Intermediate: A key building block in the synthesis and structural modification of novel cardiotonic agents.
• Reference Standard: Used for analytical method development, validation, and quality control in laboratories studying bufadienolides.
• Biochemical Research: Employed in studies investigating the interaction of cardiac glycosides with the Na+/K+-ATPase pump and related signaling pathways.
• Toxicology & Safety Assessment: Serves as a standard compound for evaluating the toxicity profile and metabolic pathways of bufalin derivatives.
• Academic Research: Utilized in university and institutional labs for fundamental research in medicinal chemistry and pharmacology.

Basic Information

Product Name	22,23-Dihydrobufalin
CAS No.	123623-38-1
Molecular Formula	C₂₄H₃₄O₅
Molecular Weight	402.53 g/mol
Synonyms	14β,15β-Epoxy-3β,5β,14-trihydroxy-19-oxo-5β-bufa-20,22-dienolide; Dihydrobufalin; Bufalin, 22,23-dihydro-; 3β,5β,14-Trihydroxy-19-oxo-5β-bufa-20,22-dienolide, 14β,15β-epoxy-; 5β-Bufa-20,22-dienolide, 3β,5β,14-trihydroxy-19-oxo-, 14β,15β-epoxy-
EINECS	Contact for details

Quality Control

Our 22,23-Dihydrobufalin is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles, verified by advanced analytical techniques including HPLC, NMR, and MS. We adhere to cGMP guidelines for pharmaceutical intermediates, ensuring the material meets the stringent requirements of research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant use and storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.