Description

Fmoc-Glu(Obzl)-Cl CAS NO 123622-36-6 is a protected amino acid derivative, specifically an Fmoc-glutamic acid benzyl ester activated as an acid chloride. This compound is a critical building block in solid-phase peptide synthesis (SPPS), enabling the controlled and efficient incorporation of glutamic acid with side-chain protection. It is primarily used by pharmaceutical researchers, peptide manufacturers, and biotechnology companies for the development of therapeutic peptides, diagnostic agents, and complex biomolecules.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key reagent for the stepwise assembly of peptide chains, particularly for introducing glutamic acid residues.
• Therapeutic Peptide Production: Synthesis of peptide-based drugs targeting metabolic disorders, oncology, and infectious diseases.
• Research & Development: Used in academic and industrial R&D labs for exploring novel peptide structures and their biological activities.
• Combinatorial Chemistry: Employed in the generation of peptide libraries for high-throughput screening in drug discovery.
• Conjugate Vaccine Development: For creating peptide-carrier protein conjugates used in modern vaccine design.
• Custom Peptide Services: A fundamental raw material for CROs and CDMOs offering bespoke peptide synthesis.

Basic Information

Product Name	Fmoc-Glu(Obzl)-Cl
CAS No.	123622-36-6
Molecular Formula	C₂₈H₂₆ClNO₆
Molecular Weight	508.0 g/mol
Synonyms	Fmoc-Glu(OBzl)-Cl; Fmoc-Glu-OBzl-Cl; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-glutamic acid 5-benzyl ester chloride; Fmoc-L-glutamic acid 5-benzyl ester chloride; Fmoc-Glu(OBzl)-OPfp (common precursor); Fmoc-Glu(O-Benzyl)-Cl; Nα-Fmoc-L-glutamic acid γ-benzyl ester acid chloride; (S)-5-(Benzyloxy)-4-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-5-oxopentanoyl chloride
EINECS	Contact for details

Quality Control

Our Fmoc-Glu(Obzl)-Cl is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency, critical for successful peptide synthesis. Each lot undergoes comprehensive analytical testing including HPLC, NMR, and optical rotation to confirm identity, purity, and chiral integrity. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (argon or nitrogen) in a desiccated environment. This compound is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Optical Rotation	-15.0° to -18.0° (c=1 in DMF)
Water Content (KF)	≤ 0.5%
Single Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.