Description

(3S)-3-Methyl-4-(tert-Buty)Diphenylsilyloxy)Butanal CAS NO 123444-68-8 is a high-value, chiral intermediate featuring a tert-butyldiphenylsilyl (TBDPS) protecting group. This compound matters for its critical role in the stereoselective synthesis of complex organic molecules, particularly in pharmaceutical research and development. It is primarily needed by fine chemical manufacturers and R&D laboratories engaged in producing active pharmaceutical ingredients (APIs), natural products, and other specialty chemicals where precise stereochemistry is essential.

Application

• Pharmaceutical Intermediate: Key chiral building block for the synthesis of protease inhibitors, antiviral agents, and other therapeutic compounds.
• Asymmetric Synthesis: Used in the construction of complex natural products and bioactive molecules requiring the (3S) stereogenic center.
• Peptidomimetics Research: Serves as a precursor for amino acid analogs and other peptide-like structures in drug discovery.
• Protecting Group Chemistry: The TBDPS-protected aldehyde functionality allows for selective reactions in multi-step synthetic sequences.
• Catalyst and Ligand Preparation: Intermediate in the manufacture of chiral catalysts and ligands for enantioselective transformations.
• Academic & Industrial R&D: Essential reagent for methodological development in organic and medicinal chemistry.

Basic Information

Product Name	(3S)-3-Methyl-4-(tert-Buty)Diphenylsilyloxy)Butanal
CAS No.	123444-68-8
Molecular Formula	C21H28O2Si
Molecular Weight	340.53 g/mol
Synonyms	(3S)-3-Methyl-4-[(1,1-Dimethylethyl)diphenylsilyl]oxy]butanal; (S)-3-Methyl-4-(tert-butyldiphenylsilyloxy)butanal; (S)-4-(tert-Butyldiphenylsilyloxy)-3-methylbutanal; TBDPS-(S)-HMBAL; (S)-HMBAL-OTBDPS; Butanal, 4-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-3-methyl-, (3S)-; (3S)-4-(tert-Butyl-diphenyl-silanyloxy)-3-methyl-butyraldehyde
EINECS	Contact for details

Quality Control

Our (3S)-3-Methyl-4-(tert-Buty)Diphenylsilyloxy)Butanal is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with exacting standards for research and process chemistry. Certificates of Analysis (COA) detailing identity, purity, and chiral excess are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) to prevent oxidation and moisture absorption. Keep away from strong bases and fluorides.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Chiral Purity (HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.