Description

3Fluoro-3Deoxyguanosine is a fluorinated nucleoside analog, a key building block in medicinal chemistry and life science research. This modified guanosine derivative is valued for its role in probing enzyme mechanisms and as a precursor in the synthesis of novel antiviral and anticancer agents. It is primarily utilized by pharmaceutical R&D departments, biotechnology companies, and academic research institutions focused on nucleoside chemistry and drug discovery.

Application

• Pharmaceutical Intermediate: Critical precursor in the synthesis of fluorinated nucleoside-based antiviral and anticancer drug candidates.
• Biochemical Research: Used as a substrate or inhibitor to study the activity and specificity of enzymes like kinases, polymerases, and nucleoside phosphorylases.
• Probe Development: Serves as a molecular probe for investigating metabolic pathways and nucleic acid interactions due to the fluorine atom's properties.
• Antisense Oligonucleotide Synthesis: Incorporated into oligonucleotides to enhance stability and modulate biological activity.
• Diagnostic Agent Development: Potential use in the creation of radiolabeled (e.g., 18F) tracers for Positron Emission Tomography (PET) imaging.

Basic Information

Product Name	3Fluoro-3Deoxyguanosine
CAS No.	123402-21-1
Molecular Formula	C10H12FN5O4
Molecular Weight	285.23 g/mol
Synonyms	3'-Fluoro-3'-deoxyguanosine; 3-F-3-dG; 9-[(2R,3R,5R)-3-Fluoro-5-(hydroxymethyl)oxolan-2-yl]-6,9-dihydro-1H-purin-6-one; 3'-Fluoro-2',3'-dideoxyguanosine; Guanosine, 3'-fluoro-3'-deoxy-; 3-Fluoro-2,3-dideoxyguanosine; 3'-F-3'-ddG
EINECS	Contact for details

Quality Control

Our 3Fluoro-3Deoxyguanosine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and moisture content. We provide a detailed Certificate of Analysis (COA) with every shipment to ensure traceability and compliance with your research or development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. Due to its hygroscopic (moisture-sensitive) nature, the container should be kept sealed in a desiccated environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.