Description

((2S,3R,4R,5R)-5-(6-Amino-9H-Purin-9-Yl)-3-Azido-4-Fluorotetrahydrofuran-2-Yl)Methanol (Wx142533) is a high-purity, structurally complex nucleoside analog featuring a unique azido and fluorine substitution pattern. This compound is a critical advanced pharmaceutical intermediate (API) for the research and development of novel antiviral and anticancer therapeutics. It is primarily required by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in cutting-edge drug discovery programs.

Application

• Antiviral Drug Development: Key intermediate in the synthesis of nucleoside reverse transcriptase inhibitors (NRTIs) and other antiviral agents targeting viral polymerases.
• Oncology Research: Building block for the creation of novel chemotherapeutic compounds designed to interfere with DNA/RNA synthesis in cancer cells.
• Proteolysis-Targeting Chimera (PROTAC) Synthesis: Used as a specialized linker or warhead component in the design of targeted protein degradation molecules.
• Biochemical Research: Serves as a substrate or inhibitor in enzymatic studies to understand nucleotide metabolism and related pathways.
• Labeled Compound Synthesis: Precursor for the preparation of isotopically labeled (e.g., 13C, 15N, 18F) analogs for pharmacokinetic and metabolic studies.
• Medicinal Chemistry Exploration: Enables structure-activity relationship (SAR) studies to optimize the potency and selectivity of nucleoside-based drug candidates.

Basic Information

Product Name	((2S,3R,4R,5R)-5-(6-Amino-9H-Purin-9-Yl)-3-Azido-4-Fluorotetrahydrofuran-2-Yl)Methanol (Wx142533)
CAS No.	123334-79-2
Molecular Formula	C11H12FN7O3
Molecular Weight	309.26 g/mol
Synonyms	9-[(2S,3R,4R,5R)-3-Azido-5-(hydroxymethyl)-4-fluorotetrahydrofuran-2-yl]-9H-purin-6-amine; 3'-Azido-4'-fluoro-2',3'-dideoxyadenosine derivative; 3'-Azido-4'-fluoro-2',3'-dideoxyadenosine analog; 3'-N3-4'-F-ddA intermediate; Fluorinated azido nucleoside; Wx-142533; Azido-fluoro nucleoside alcohol; 6-Amino-9-[(2S,3R,4R,5R)-3-azido-5-(hydroxymethyl)-4-fluorotetrahydrofuran-2-yl]purine
EINECS	Contact for details

Quality Control

Our ((2S,3R,4R,5R)-5-(6-Amino-9H-Purin-9-Yl)-3-Azido-4-Fluorotetrahydrofuran-2-Yl)Methanol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high chemical purity and structural integrity, meeting the stringent requirements for pharmaceutical intermediate applications. Certificates of Analysis (COA) detailing purity (by HPLC), identity confirmation (by NMR, IR, and MS), and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. Under these conditions, the product is stable for extended periods. The container should be kept in a dry, well-ventilated area. Allow the sealed container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.