Description

2'-Fluoro-2'-Deoxy-Arabinofuranosyl-Adenosine is a chemically modified nucleoside analog, a key building block in medicinal chemistry and life science research. This compound is valued for its role as a versatile intermediate in the synthesis of novel antiviral and anticancer therapeutics, particularly in the development of modified oligonucleotides. It is primarily utilized by pharmaceutical R&D departments, biotechnology companies, and academic research institutions focused on nucleoside chemistry and drug discovery.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel antiviral and anticancer nucleoside analogs.
• Antisense Oligonucleotide (ASO) Synthesis: Used to incorporate modified bases into oligonucleotides for therapeutic and research applications.
• Proteomics & Genomics Research: Serves as a specialized reagent in studying nucleic acid structure, function, and enzyme interactions.
• Biochemical Probe Development: Employed in creating labeled or modified probes for diagnostic assays and mechanistic studies.
• Medicinal Chemistry & SAR Studies: Essential for structure-activity relationship (SAR) research to optimize drug candidate efficacy and selectivity.
• Reference Standard: Used as a high-purity analytical standard for quality control and method development in regulatory filings.

Basic Information

Product Name	2'-Fluoro-2'-Deoxy-Arabinofuranosyl-Adenosine
CAS No.	123334-75-8
Molecular Formula	C15H16FN5O4
Molecular Weight	349.32 g/mol
Synonyms	2'-F-2'-Deoxy-Arabinofuranosyl-Adenosine; 2'-Fluoro-2'-deoxyarabinofuranosyladenine; 2'-F-Ara-A; 9-((2R,3S,4S,5R)-5-Fluoro-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl)purin-6-amine; 2'-Fluoro-2'-deoxyarabinofuranosyladenosine; 2'-F-dAraA; 2'-Fluoro-arabinofuranosyladenosine; 2'-F-2'-deoxy-β-D-arabinofuranosyladenine
EINECS	Contact for details

Quality Control

Our 2'-Fluoro-2'-Deoxy-Arabinofuranosyl-Adenosine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and analytical methods is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a desiccated environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.