Description

2,3,4,6-Tetrafluorobenzoyl Chloride is a highly reactive fluorinated aromatic acid chloride derivative, serving as a critical building block for introducing the tetrafluorobenzoyl moiety into target molecules. Its value lies in enabling the synthesis of advanced intermediates with enhanced properties like metabolic stability and lipophilicity for demanding applications. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors.

Application

• Pharmaceutical Intermediates: Key reagent for synthesizing active pharmaceutical ingredients (APIs), particularly in the development of fluorinated drugs where the tetrafluorophenyl group can improve bioavailability and binding affinity.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where fluorination often increases compound efficacy and environmental stability.
• Liquid Crystal & OLED Materials: Acts as a precursor for fluorinated components in electronic display materials, contributing to improved performance and durability.
• Polymer Modification: Employed to introduce fluorinated aromatic groups into polymer chains, enhancing material properties such as chemical resistance, thermal stability, and surface characteristics.
• Peptide & Protein Chemistry: Useful as an acylating agent for modifying amino acids or protecting groups in complex peptide synthesis.
• Dye & Pigment Manufacturing: Serves as an intermediate for creating specialized fluorinated dyes with unique color fastness and spectral properties.
• Cross-Coupling Reactions: A valuable substrate in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille) to create complex biaryl structures for various applications.
• Chemical Research & Development: A versatile tool for exploring new synthetic pathways and creating novel fluorinated compounds in academic and industrial R&D settings.

Basic Information

Item	Details
Product Name	2,3,4,6-Tetrafluorobenzoyl Chloride
CAS No.	123016-51-3
Molecular Formula	C7HClF4O
Molecular Weight	212.53 g/mol
Synonyms	2,3,4,6-Tetrafluorobenzoyl chloride; Benzoyl chloride, 2,3,4,6-tetrafluoro-; Tetrafluorobenzoyl chloride; 2,3,4,6-Tetrafluorobenzoic acid chloride; Perfluorobenzoyl chloride (common name for the specific isomer); 2,3,4,6-Tetrafluorobenzenecarbonyl chloride
EINECS	Contact for details

Quality Control

Our 2,3,4,6-Tetrafluorobenzoyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, assay, impurity profile, and moisture content is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and reacts with water, strong acids, and bases. Keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation from moisture and ensure maximum shelf life.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.