Description

7-Thio-8-Oxoguanosine is a chemically modified nucleoside analog of significant interest in biochemical and pharmaceutical research. This compound serves as a critical building block and research tool for investigating nucleic acid structure, function, and the development of novel therapeutic agents. It is primarily sought after by research institutions and pharmaceutical companies engaged in nucleic acid chemistry, antiviral drug discovery, and molecular biology studies. The unique thio and oxo substitutions at the 7 and 8 positions of the guanosine base impart distinct chemical properties, making it valuable for probing enzyme mechanisms and designing nucleotide-based inhibitors.

Application

• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies, particularly with nucleoside kinases and polymerases.
• Antiviral Drug Development: Serves as a precursor or active component in the synthesis of nucleoside analogs targeting viral replication.
• Nucleic Acid Probe Synthesis: Incorporated into oligonucleotides to study RNA/DNA structure, stability, and protein interactions.
• Metabolic Pathway Analysis: Employed as a tracer or modulator to investigate purine and nucleotide salvage pathways in cellular systems.
• Enzyme Mechanism Studies: Utilized to elucidate the catalytic mechanisms of enzymes involved in nucleotide metabolism and modification.
• Reference Standard: Acts as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Item	Detail
Product Name	7-Thio-8-Oxoguanosine
CAS No.	122970-43-8
Molecular Formula	C₁₀H₁₃N₅O₅S
Molecular Weight	315.31 g/mol
Synonyms	8-Oxo-7-thioguanosine; 7-Thio-8-oxoguanosine; 8-Oxo-7-thio-guanosine; Guanosine, 7-thio-8-oxo-; 7-Thio-8-oxo-Guanosine; 7-Thio-8-oxo-guanosine; 8-Oxoguanosine-7-thiol; 7-Thio-8-oxoguanosine (8OG-SH)
EINECS	Contact for details

Quality Control

Our 7-Thio-8-Oxoguanosine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and stringent controls for residual solvents and moisture. We provide Certificates of Analysis (COA) with each shipment, detailing all test results against established specifications. Our quality commitment ensures material integrity for sensitive research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider desiccation and storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.