Description

7-Thia-8-Oxoguanosine is a chemically modified nucleoside analog, a key building block in advanced pharmaceutical and biochemical research. This compound is valued for its unique structure, where a sulfur atom replaces an oxygen atom, imparting distinct electronic and binding properties. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutics, diagnostic probes, and as a critical intermediate in organic synthesis.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the synthesis of novel antiviral and anticancer nucleoside analogs.
• Biochemical Research: Used as a modified substrate to study enzyme mechanisms, particularly those involving purine metabolism and nucleic acid processing.
• Probe Development: Acts as a building block for creating fluorescent or affinity-labeled probes for nucleic acid detection and imaging.
• Organic Synthesis: Employed as a specialized reagent for introducing modified guanine bases into complex molecular architectures.
• Antisense Oligonucleotide Research: Incorporated into oligonucleotide sequences to modulate stability, binding affinity, and biological activity.

Basic Information

Product Name	7-Thia-8-Oxoguanosine
CAS No.	122970-40-5
Molecular Formula	C10H11N5O5S
Molecular Weight	313.29 g/mol
Synonyms	8-Oxo-7-thiaguanosine; 7-Thia-8-oxoguanosine; 8-Oxo-7-thia-guanosine; 2-Amino-6,8-dihydroxy-7-thia-purine riboside; 6-Amino-2,8-dihydroxy-7-thia-purine riboside; Guanine, 7-thia-8-oxo-, riboside; 7-Thia-8-oxo-Guanosine
EINECS	Contact for details

Quality Control

Our 7-Thia-8-Oxoguanosine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing including HPLC for purity, NMR and MS for structural confirmation, and stringent controls for residual solvents and moisture. Certificates of Analysis (COA) detailing all specifications are provided to ensure traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.