Description

6-Chloro-2',3'-Dideoxyguanosine is a chemically modified nucleoside analog of significant interest in pharmaceutical research and development. This compound serves as a crucial synthetic intermediate and building block for the creation of novel antiviral and anticancer agents. It is primarily utilized by research institutions, pharmaceutical companies, and fine chemical manufacturers engaged in the synthesis of nucleoside-based therapeutics. The product is offered with a focus on high purity and reliable supply to support critical R&D and production workflows.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of nucleoside reverse transcriptase inhibitors (NRTIs) and other antiviral drugs.
• Antiviral Research: Used as a precursor in the development of novel compounds targeting viruses such as HIV, HBV, and HCV.
• Oncology Drug Discovery: Serves as a scaffold for creating potential anticancer agents that target DNA synthesis and repair mechanisms.
• Biochemical Research: Employed in studies investigating nucleotide metabolism, enzyme inhibition, and the mechanism of action of nucleoside analogs.
• Fine Chemical Synthesis: Utilized in custom synthesis and the production of specialized nucleotide libraries for screening.
• Pro-drug Development: Acts as a core structure for designing pro-drugs to enhance bioavailability and targeting.

Basic Information

Product Name	6-Chloro-2',3'-Dideoxyguanosine
CAS No.	122970-35-8
Molecular Formula	C10H12ClN5O3
Molecular Weight	285.69 g/mol
Synonyms	6-Chloro-2',3'-dideoxyguanosine; 2',3'-Dideoxy-6-chloroguanosine; 6-Chloro-ddG; 9-[(2R,5S)-5-(Hydroxymethyl)oxolan-2-yl]-6-chloro-1,9-dihydro-2H-purin-2-one; 6-Cl-ddG; 2',3'-Dideoxy-6-chloro-9H-purin-9-yl-β-D-ribofuranose; 6-Chloro-2',3'-dideoxyguanosine (6-Cl-ddG); 6-Chloro-9-(2,3-dideoxy-β-D-*erythro*-pentofuranosyl)guanine
EINECS	Contact for details

Quality Control

Our 6-Chloro-2',3'-Dideoxyguanosine is manufactured under strict quality control protocols to ensure high chemical purity and batch-to-batch consistency, suitable for research and pharmaceutical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable, and our quality systems are designed to meet the stringent requirements of our global clientele.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Total impurities ≤2.0%
Solubility	Soluble in DMSO, DMF; slightly soluble in methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.