Description

Pacidamycin 5 is a specialized nucleoside antibiotic belonging to the pacidamycin family, a group of compounds known for their unique uridyl peptide structure and potent antibacterial activity. This compound is of significant interest in pharmaceutical research and development due to its mechanism of action, which targets bacterial cell wall biosynthesis, offering a pathway for novel antibiotic discovery. It is primarily utilized by research institutions, pharmaceutical companies, and biotechnology firms engaged in antimicrobial drug discovery, mechanism of action studies, and the synthesis of new therapeutic agents.

Application

• Antibiotic Research & Development: Serves as a key reference standard and active pharmaceutical ingredient (API) in the discovery and development of new antibacterial agents.
• Mechanistic Studies: Used in biochemical and microbiological assays to study the inhibition of bacterial translocase I (MraY), a critical enzyme in peptidoglycan synthesis.
• Structure-Activity Relationship (SAR) Analysis: Employed as a core scaffold for chemical modification to explore and enhance antibacterial potency and spectrum.
• Pharmacological Screening: Utilized in high-throughput screening platforms to identify compounds with synergistic or additive effects against multidrug-resistant pathogens.
• Academic Research: A vital tool in university and institutional labs for fundamental research in microbiology, medicinal chemistry, and infectious diseases.
• Biochemical Reagent: Acts as a specific inhibitor in enzymatic studies related to bacterial cell wall assembly pathways.

Basic Information

Product Name	Pacidamycin 5
CAS No.	122855-43-0
Molecular Formula	C₃₈H₄₈N₁₀O₁₄
Molecular Weight	876.85 g/mol
Synonyms	Pacidamycin D; Antibiotic MJ 347-81F4; Uridyl peptide antibiotic; Pacidamycin 5 (MJ347-81F4); 5'-O-[N-[3-[[5-[(2-Amino-2-carboxyethyl)amino]-5-deoxy-β-D-ribofuranosyl]amino]-2-hydroxybenzoyl]glycyl]uridine; 5'-O-[N-[3-[[5-[(2-Amino-2-carboxyethyl)amino]-5-deoxy-β-D-ribofuranosyl]amino]-2-hydroxybenzoyl]glycyl]-1-β-D-ribofuranosyluracil
EINECS	Contact for details

Quality Control

Our Pacidamycin 5 is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity determination and spectroscopic methods for structural confirmation. A detailed Certificate of Analysis (COA), providing full specifications and test results, is supplied with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain integrity. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥95.0%
Water Content (KF)	≤5.0%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Complies with ICH guidelines
Biological Activity (MIC)	Reported value provided

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.