Description

2'-Deoxy-2'-Fluorothymidine is a fluorinated nucleoside analog of significant interest in advanced pharmaceutical research and development. This compound serves as a critical building block and a key intermediate in the synthesis of novel antiviral and anticancer agents, particularly in the development of oligonucleotide therapeutics. It is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors who require high-purity intermediates for drug discovery, process development, and the production of active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel antiviral drugs, including potential treatments for hepatitis and other viral infections.
• Anticancer Agent Research: Used in the development and study of nucleoside analogs designed to inhibit cancer cell proliferation.
• Oligonucleotide Synthesis: Serves as a modified nucleoside monomer for the solid-phase synthesis of fluorinated antisense oligonucleotides and siRNAs.
• Biochemical Research: Employed as a substrate or inhibitor in enzymatic studies to investigate metabolic pathways and nucleic acid biochemistry.
• Radiopharmaceuticals: Potential precursor for the synthesis of fluorinated tracers used in Positron Emission Tomography (PET) imaging.
• Process Chemistry & Scale-Up: Used by contract development and manufacturing organizations (CDMOs) for the pilot and commercial-scale production of active pharmaceutical ingredients (APIs).

Basic Information

Product Name	2'-Deoxy-2'-Fluorothymidine
CAS No.	122799-38-6
Molecular Formula	C10H13FN2O5
Molecular Weight	260.22 g/mol
Synonyms	2'-Fluoro-2'-deoxythymidine; 2'-F-dT; 1-((2R,4S,5R)-4-Fluoro-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione; 2'-Deoxy-2'-fluorothymidine; 2'-Fluorothymidine; FLT; FdT; Alovudine (pharmaceutical context)
EINECS	Contact for details

Quality Control

Our 2'-Deoxy-2'-Fluorothymidine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and pharmaceutical applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and tests for residual solvents and moisture. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container should be kept in a desiccated environment. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.