Description

N3-Tetrahydrofurfuryluridine is a modified nucleoside derivative, a key building block in advanced oligonucleotide synthesis. This compound matters for its role in creating chemically stable and biologically active nucleic acid analogs, which are essential for therapeutic and diagnostic applications. It is primarily needed by research institutions and manufacturers in the pharmaceutical and biotechnology industries developing next-generation antisense oligonucleotides, siRNA, and other nucleic acid-based therapeutics.

Application

• Pharmaceutical Intermediate: A critical raw material in the synthesis of therapeutic oligonucleotides for treating genetic disorders, cancers, and viral infections.
• Antisense Oligonucleotide (ASO) Synthesis: Used to incorporate modified uridine residues that enhance nuclease resistance and target affinity of ASO drugs.
• siRNA and miRNA Synthesis: Serves as a building block to improve the stability and efficacy of RNA interference (RNAi) therapeutics.
• Diagnostic Probe Development: Employed in creating labeled nucleotide probes for advanced molecular diagnostics and genomic research.
• Medicinal Chemistry Research: A valuable tool for structure-activity relationship (SAR) studies in drug discovery programs focused on nucleic acid targets.
• Bioconjugation and Labeling: The tetrahydrofurfuryl group provides a handle for further chemical modifications and attachment of reporter molecules.

Basic Information

Product Name	N3-Tetrahydrofurfuryluridine
CAS No.	122666-26-6
Molecular Formula	C14H20N2O7
Molecular Weight	328.32 g/mol
Synonyms	1-(3,4-Dihydro-2H-furan-2-ylmethyl)uridine; 3-(Tetrahydrofurfuryl)uridine; N3-THF-Uridine; Uridine, N3-(tetrahydro-2-furanylmethyl)-; 5'-O-(4,4'-Dimethoxytrityl)-N3-tetrahydrofurfuryluridine (DMT-protected precursor); 2'-Deoxy-2'-fluoro-N3-tetrahydrofurfuryluridine (related analog); N3-THF-Urd
EINECS	Contact for details

Quality Control

Our N3-Tetrahydrofurfuryluridine is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency for sensitive pharmaceutical applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP guidelines where applicable, and our quality commitment supports compliance with ICH Q7 and other relevant pharmacopeial standards for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry, inert conditions to maintain stability. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (HPLC, Area%)	≥ 99.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.