Description

5'-o-Benzoyl-3'-Deoxythymidine is a key nucleoside derivative and a vital building block in organic synthesis. This compound matters for its role as a protected intermediate in the production of modified oligonucleotides and nucleoside analogs. It is primarily needed by pharmaceutical R&D teams, biotechnology companies, and fine chemical manufacturers focused on developing antiviral and anticancer therapeutics, as well as advanced diagnostic probes.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel nucleoside-based antiviral and anticancer drugs.
• Oligonucleotide Synthesis: Used as a protected monomer for the solid-phase or solution-phase synthesis of modified DNA/RNA strands for research and therapeutic applications.
• Prodrug Development: Serves as a key starting material for creating prodrugs designed to improve the bioavailability and targeting of active nucleoside agents.
• Biochemical Research: Employed in studies investigating DNA replication, repair mechanisms, and enzyme-substrate interactions.
• Diagnostic Probe Manufacturing: Utilized in the development of labeled nucleotides for use in sequencing, PCR, and other molecular diagnostic techniques.
• Antisense Therapy Development: Acts as a building block for antisense oligonucleotides designed to modulate gene expression.

Basic Information

Product Name	5'-o-Benzoyl-3'-Deoxythymidine
CAS No.	122621-07-2
Molecular Formula	C17H18N2O5
Molecular Weight	330.34 g/mol
Synonyms	3'-Deoxythymidine 5'-benzoate; 5'-O-Benzoyl-3'-deoxythymidine; 1-[(2R,5S)-5-(Benzoyloxy)tetrahydrofuran-2-yl]-5-methylpyrimidine-2,4(1H,3H)-dione; Thymidine 5'-benzoate; 3'-Deoxy-5'-O-benzoylthymidine; 5'-O-Benzoylthymidine 3'-deoxy
EINECS	Contact for details

Quality Control

Our 5'-o-Benzoyl-3'-Deoxythymidine is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency, suitable for demanding research and cGMP starting material applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant ICH guidelines and can provide material meeting custom specifications for advanced pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.