Description

4-Azido-2,3,5,6-Tetrafluorobenzamide is a specialized fluorinated aromatic compound featuring a reactive azido functional group. This unique structure makes it a valuable high-purity building block for advanced organic synthesis and materials science research. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty polymer industries for creating novel molecules with tailored properties.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for incorporating fluorine and nitrogen-rich motifs to modulate bioavailability and metabolic stability.
• Agrochemical Research: Used in developing new herbicides, fungicides, and insecticides where the tetrafluorophenyl and azide groups contribute to unique biological activity and environmental fate profiles.
• Click Chemistry Reagent: Acts as a versatile partner in copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions for bioconjugation, polymer functionalization, and materials surface modification.
• Materials Science: Employed in the synthesis of advanced polymers, liquid crystals, and energetic materials, where its fluorinated aromatic core imparts thermal stability and specific electronic properties.
• Chemical Biology Probe: Utilized for photoaffinity labeling and activity-based protein profiling to study enzyme mechanisms and identify drug targets.

Basic Information

Product Name	4-Azido-2,3,5,6-Tetrafluorobenzamide
CAS No.	122616-98-2
Molecular Formula	C7H2F4N4O
Molecular Weight	234.11 g/mol
Synonyms	2,3,5,6-Tetrafluoro-4-azidobenzamide; 4-Azidotetrafluorobenzamide; Benzamide, 4-azido-2,3,5,6-tetrafluoro-; 4-Azido-perfluorobenzamide; Tetrafluoro-4-azidobenzamide; 4-N3-C6F4-CONH2; 4-Azido-2,3,5,6-tetrafluorobenzoic acid amide
EINECS	Contact for details

Quality Control

Every batch of 4-Azido-2,3,5,6-Tetrafluorobenzamide is manufactured and tested under strict quality management protocols to ensure consistency and reliability for research and development applications. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flames.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.