Description

2',3'-Dideoxy-4-Thiouridine is a chemically modified nucleoside analog, distinguished by the incorporation of a sulfur atom at the 4-position of the pyrimidine ring and the absence of hydroxyl groups at the 2' and 3' positions of the sugar moiety. This unique structure is critical for its role as a key intermediate and building block in the synthesis of modified oligonucleotides and potential antiviral or antiretroviral agents. It is primarily utilized by research institutions and pharmaceutical companies engaged in nucleotide chemistry, medicinal chemistry, and the development of novel therapeutic candidates.

Application

• Nucleic Acid Research: Serves as a vital building block for the solid-phase synthesis of oligonucleotides containing thionucleobases, enabling studies on RNA structure, function, and stability.
• Medicinal Chemistry & Drug Discovery: Used as a core scaffold or intermediate in the development of novel nucleoside analog prodrugs targeting viral polymerases.
• Antiviral Agent Development: Investigated for its potential incorporation into oligonucleotide sequences designed to inhibit viral replication, particularly for HIV and hepatitis viruses.
• Biochemical Probe Synthesis: Facilitates the creation of labeled or modified nucleotides for use as probes in molecular biology assays and diagnostic research.
• Academic & Industrial R&D: Employed in fundamental research exploring the structure-activity relationships (SAR) of modified nucleosides and their metabolic pathways.

Basic Information

Product Name	2',3'-Dideoxy-4-Thiouridine
CAS No.	122568-04-1
Molecular Formula	C9H12N2O4S
Molecular Weight	244.27 g/mol
Synonyms	4-Thio-2',3'-dideoxyuridine; dd4ThioU; 2',3'-Dideoxy-4-thiouridine; 1-[(2R,5S)-5-(Hydroxymethyl)oxolan-2-yl]-4-sulfanylpyrimidin-2-one; 4-Thio-ddU; 4-Thio-2',3'-ddU
EINECS	Contact for details

Quality Control

Every batch of 2',3'-Dideoxy-4-Thiouridine is manufactured and tested under strict quality management protocols. Our products undergo rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications and test results are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.