Description

3'-Deoxy-4-Thiothymidine is a chemically modified nucleoside analog, distinguished by the substitution of an oxygen atom with sulfur at the 4-position of the thymidine base. This structural modification is of significant interest for its potential to alter biological activity and metabolic stability, making it a valuable building block in advanced pharmaceutical research and development. It is primarily utilized by research scientists and process chemists in the fields of antiviral drug discovery, nucleoside chemistry, and the synthesis of novel therapeutic oligonucleotides.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the research and development of novel antiviral and anticancer nucleoside analogs.
• Biochemical Research: Used as a probe or substrate in enzymatic studies to investigate the mechanism of action of thymidine kinases and other nucleoside-metabolizing enzymes.
• Antisense Oligonucleotide Synthesis: Serves as a modified building block for incorporating thionucleoside linkages into oligonucleotides to enhance nuclease resistance and binding affinity.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies to explore the impact of sulfur substitution on the pharmacological profile of nucleoside drugs.
• Reference Standard: Used as an analytical standard in quality control laboratories for the identification and quantification of related compounds.

Basic Information

Product Name	3'-Deoxy-4-Thiothymidine
CAS No.	122568-03-0
Molecular Formula	C10H14N2O4S
Molecular Weight	258.29 g/mol
Synonyms	4-Thio-2'-deoxythymidine; 4-Thiothymidine 2'-deoxy-; 1-(2-Deoxy-β-D-erythro-pentofuranosyl)-4-thiothymine; 2'-Deoxy-4-thiothymidine; 4-Thio-dT; 4-S-dT; D4T-4-thio
EINECS	Contact for details

Quality Control

Our 3'-Deoxy-4-Thiothymidine is manufactured under a quality management system and undergoes rigorous analytical testing to ensure high purity and batch-to-batch consistency. Standard quality parameters include identity confirmation by spectroscopic methods and purity determination by HPLC. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with each shipment to support your research and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.