Description

2',3'-Didehydro-2',3'-Dideoxy-4-Thiouridine is a chemically modified nucleoside analog of significant interest in pharmaceutical research and development. This compound serves as a critical building block and reference standard in the synthesis and study of novel antiviral and anticancer agents. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers engaged in nucleoside chemistry. The product, with CAS number 122568-02-9, is supplied under stringent quality control to ensure reliability for sensitive applications.

Application

• Pharmaceutical Intermediate: A key synthetic precursor for the development of modified nucleoside-based therapeutics.
• Antiviral Research: Used in the study and synthesis of potential antiviral compounds targeting viral polymerases.
• Oncology Research: Serves as a scaffold for investigating novel anticancer agents that interfere with DNA/RNA synthesis.
• Biochemical Probe: Employed in mechanistic studies to understand enzyme interactions and metabolic pathways involving nucleosides.
• Reference Standard: Provides a high-purity standard for analytical method development, validation, and quality control in API manufacturing.
• Medicinal Chemistry: Utilized in structure-activity relationship (SAR) studies to optimize the potency and selectivity of drug candidates.

Basic Information

Product Name	2',3'-Didehydro-2',3'-Dideoxy-4-Thiouridine
CAS No.	122568-02-9
Molecular Formula	C9H10N2O4S
Molecular Weight	242.25 g/mol
Synonyms	4-Thio-2',3'-didehydro-2',3'-dideoxyuridine; 4-Thio-d4U; D4-4-Thiouridine; 2',3'-Didehydro-2',3'-dideoxy-4-thiouridine; 1-[(2R,5S)-5-(Hydroxymethyl)-2,5-dihydrofuran-2-yl]-4-pyrimidinethione; 4-Thio-2',3'-dideoxy-2',3'-didehydrouridine
EINECS	Contact for details

Quality Control

Our 2',3'-Didehydro-2',3'-Dideoxy-4-Thiouridine is manufactured under a quality management system and undergoes rigorous analytical testing to ensure it meets the high standards required for research and pharmaceutical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We can supply material compliant with various pharmacopeial standards upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.