Description

4',5'-Didehydro-5'-Deoxy-5'-Fluoroadenosine is a chemically modified nucleoside analog of significant interest in advanced pharmaceutical research and development. This compound is valued for its potential as a key synthetic intermediate or active pharmaceutical ingredient (API) in the creation of novel antiviral and anticancer therapeutics. It is primarily utilized by research institutions, pharmaceutical companies, and biotechnology firms engaged in the synthesis of next-generation nucleoside-based drugs. The product is supplied with a high level of purity and batch-to-batch consistency to meet the stringent demands of modern drug discovery and process chemistry.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of novel antiviral and anticancer nucleoside analogs.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies to investigate metabolic pathways and mechanisms of action.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies to optimize the potency and selectivity of drug candidates.
• Antiviral Drug Development: Investigated for its potential activity against a range of viral targets due to its modified sugar moiety.
• Oncology Research: Explored for its ability to interfere with DNA/RNA synthesis in rapidly dividing cancer cells.
• Process Development: Used in scaling up synthetic routes for the commercial production of specialty active pharmaceutical ingredients (APIs).

Basic Information

Product Name	4',5'-Didehydro-5'-Deoxy-5'-Fluoroadenosine
CAS No.	122289-05-8
Molecular Formula	C₁₁H₁₂FN₅O₃
Molecular Weight	281.25 g/mol
Synonyms	5'-Deoxy-5'-fluoro-4',5'-didehydroadenosine; 4',5'-Didehydro-5'-deoxy-5'-fluoroadenosine; 5'-Fluoro-4',5'-didehydro-5'-deoxyadenosine; 9-[(2R,3R,4S)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]purin-6-amine; 5'-Fluoro-5'-deoxy-4',5'-didehydroadenosine; Adenosine, 4',5'-didehydro-5'-deoxy-5'-fluoro-
EINECS	Contact for details

Quality Control

Our 4',5'-Didehydro-5'-Deoxy-5'-Fluoroadenosine is manufactured under strict quality management systems. Each batch is subjected to rigorous analytical testing, including HPLC for purity and identity confirmation (NMR, IR, MS), to ensure it meets the high standards required for research and pharmaceutical applications. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment. We support compliance with cGMP and ICH guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.