Description

4-Bromo-2,3,5,6-tetrafluorobenzoyl chloride is a highly reactive and versatile organofluorine building block, essential for introducing the 4-bromo-2,3,5,6-tetrafluorobenzoyl moiety into complex molecular architectures. Its core value lies in enabling precise structural modifications in advanced chemical synthesis, particularly where electronic and steric properties are critical. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for fluorinated drug candidates targeting CNS disorders, oncology, and metabolic diseases.
• Agrochemical Synthesis: Used to construct advanced herbicides, fungicides, and pesticides where the fluorine atoms enhance biological activity, stability, and lipophilicity.
• Liquid Crystal & OLED Materials: Serves as a critical building block for fluorinated liquid crystals and organic light-emitting diode (OLED) materials, improving electronic properties and device performance.
• Polymer & Resin Modifier: Incorporated into specialty polymers and epoxy resins to impart unique thermal, chemical, and surface properties.
• Cross-Coupling Reactions: The bromine substituent makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) to create complex biaryl structures.
• Peptide & Protein Labeling: The acyl chloride group reacts readily with amines, making it useful for labeling biomolecules for research and diagnostic applications.

Basic Information

Item	Details
Product Name	4-Bromo-2,3,5,6-Tetrafluorobenzoyl Chloride
CAS No.	122033-54-9
Molecular Formula	C7BrClF4O
Molecular Weight	291.43 g/mol
Synonyms	4-Bromo-2,3,5,6-tetrafluorobenzoic acid chloride; 2,3,5,6-Tetrafluoro-4-bromobenzoyl chloride; p-Bromotetrafluorobenzoyl chloride; Benzoyl chloride, 4-bromo-2,3,5,6-tetrafluoro-; 4-Bromo-perfluorobenzoyl chloride
EINECS	Contact for details

Quality Control

Our 4-Bromo-2,3,5,6-tetrafluorobenzoyl chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high purity and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support cGMP and ISO 9001 standards for pharmaceutical and industrial applications, ensuring full traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent hydrolysis. Keep away from strong bases, oxidizers, and sources of ignition.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 0.5%, Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.