Description

Ketoconazole Oleate is a specific chemical derivative of the broad-spectrum antifungal agent ketoconazole, synthesized by esterification with oleic acid. This modification is designed to alter the physicochemical properties of the parent compound, potentially enhancing its solubility in lipophilic matrices and compatibility with specific formulation technologies. It is a critical intermediate for researchers and manufacturers in the pharmaceutical and personal care industries seeking to develop novel antifungal products. The compound is identified by the CAS registry number 121917-58-6.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of advanced antifungal drug formulations and prodrugs.
• Topical Antifungal Preparations: Used in the development of creams, ointments, and lotions for treating skin infections like athlete's foot, ringworm, and seborrheic dermatitis.
• Veterinary Medicine: Incorporated into antifungal treatments for skin and hoof conditions in livestock and companion animals.
• Cosmetic & Personal Care: Potential use in antidandruff shampoos and scalp treatments where antifungal activity is required.
• Research & Development: Employed in biochemical and pharmacological studies to investigate new mechanisms of antifungal action and drug delivery systems.
• Industrial Preservative: Exploration of its use as a fungistatic agent in protecting industrial materials and products from microbial degradation.

Basic Information

Product Name	Ketoconazole Oleate
CAS No.	121917-58-6
Molecular Formula	C42H67ClN2O4
Molecular Weight	699.45 g/mol
Synonyms	Ketoconazole oleic acid ester; 1-[4-(4-{[(2R,4S)-2-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazin-1-yl]ethan-1-one oleate; cis-9-Octadecenoic acid compound with ketoconazole (1:1); Ketoconazole oleate salt
EINECS	Contact for details

Quality Control

Our Ketoconazole Oleate is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including identification, purity assay, and impurity profiling, to ensure it meets precise specifications. A Certificate of Analysis (COA) documenting these results is provided with each shipment to guarantee traceability and compliance. We adhere to cGMP principles where applicable to support our customers in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from strong oxidizing agents and incompatible materials. For long-term storage, consider conditions under an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.