Description

2',5'-Dideoxy-3'-(4-Fluorosulfonylbenzoyl)Adenosine is a chemically modified adenosine analog designed as a potent and selective inhibitor of adenylate cyclase, acting as a P-site antagonist. This compound is a critical biochemical tool for studying intracellular cAMP signaling pathways and G-protein coupled receptor (GPCR) function. It is primarily utilized by researchers and developers in pharmaceutical R&D, biochemical research, and diagnostic assay development.

Application

• Biochemical Research: A key tool for investigating the role of adenylate cyclase and cAMP in cellular signal transduction pathways.
• Pharmaceutical Development: Used in target validation and screening assays for drugs targeting heart failure, asthma, and other conditions modulated by cAMP.
• Enzymology Studies: Serves as a substrate analog to study the kinetics and inhibition mechanisms of adenylate cyclase isoforms.
• Cell Biology: Employed to manipulate intracellular cAMP levels to study effects on cell proliferation, differentiation, and gene expression.
• Diagnostic Reagent Manufacturing: Potential use as a component in specialized diagnostic kits for research purposes.

Basic Information

Item	Detail
Product Name	2',5'-Dideoxy-3'-(4-Fluorosulfonylbenzoyl)Adenosine
CAS No.	121878-15-7
Molecular Formula	C17H17FN5O7S
Molecular Weight	455.41 g/mol
Synonyms	2',5'-Dideoxy-3'-(4-Fluorosulfonylbenzoyl)Adenosine; 3'-O-(4-Fluorosulfonylbenzoyl)adenosine 2',5'-dideoxy; 2',5'-Dideoxyadenosine 3'-(4-fluorosulfonylbenzoate); FSBA-2',5'-ddA; Adenylate Cyclase Inhibitor (P-site); 3'-(p-Fluorosulfonylbenzoyl)-2',5'-dideoxyadenosine; P-site inhibitor of adenylate cyclase
EINECS	Contact for details

Quality Control

Our 2',5'-Dideoxy-3'-(4-Fluorosulfonylbenzoyl)Adenosine is produced under strict quality management systems. Each batch undergoes rigorous analytical testing including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. Certificates of Analysis (COA) detailing all specifications are provided to ensure traceability and compliance with research-grade material standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. The product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability. Allow the vial to equilibrate to room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.