Description

2' 5'-Dideoxyadenosine 3'-Monophosphate is a chemically modified nucleotide analog of significant interest in biochemical and pharmaceutical research. This compound serves as a crucial building block and research tool for studying enzyme mechanisms, particularly those involving nucleotide-dependent processes. It is primarily utilized by research institutions, pharmaceutical R&D departments, and biotechnology companies engaged in the development of novel therapeutic agents and diagnostic tools. Its specific structure makes it valuable for probing the active sites of kinases, polymerases, and other nucleotide-binding proteins.

Application

• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies to investigate the mechanisms of phosphotransferases and nucleotide-metabolizing enzymes.
• Pharmaceutical R&D: Serves as a key intermediate or precursor in the synthesis of novel nucleoside-based antiviral or anticancer prodrug candidates.
• Molecular Biology: Employed in the study of DNA/RNA synthesis and repair pathways, acting as a chain terminator or probe for specific polymerase activities.
• Enzyme Kinetics: Utilized to determine kinetic parameters (Km, Vmax) and inhibition constants (Ki) for enzymes that recognize adenosine derivatives.
• Diagnostic Development: Can be incorporated into assay systems for the detection and quantification of specific enzymatic activities in clinical or research samples.
• Chemical Biology: Acts as a tool compound for labeling or cross-linking studies to map nucleotide-binding sites within proteins or complex biological structures.

Basic Information

Product Name	2' 5'-Dideoxyadenosine 3'-Monophosphate
CAS No.	121878-11-3
Molecular Formula	C10H14N5O5P
Molecular Weight	315.22 g/mol
Synonyms	2',5'-Dideoxyadenosine 3'-monophosphate; 2',5'-ddA-3'-monophosphate; 9-[(2R,3S,5R)-3-(Dihydrogen phosphate)-5-(hydroxymethyl)oxolan-2-yl]-9H-purin-6-amine; Adenosine, 2',5'-dideoxy-, 3'-(dihydrogen phosphate); 2',5'-Dideoxyadenosine-3'-phosphate; 3'-Monophosphate of 2',5'-dideoxyadenosine; ddA-3'-P
EINECS	Contact for details

Quality Control

Our 2' 5'-Dideoxyadenosine 3'-Monophosphate is produced under strict quality management protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot undergoes comprehensive analytical testing including HPLC for purity, NMR for structural confirmation, and mass spectrometry. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. Due to its hygroscopic nature, the container should be kept sealed in a desiccator or under an inert atmosphere for long-term storage to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.