Description

3-Pyridinecarbonyl Fluoride, 6-Chloro- (9Ci) is a specialized fluorinated pyridine derivative, serving as a high-value synthetic intermediate in advanced organic synthesis. Its core value lies in the reactive acyl fluoride group, which enables efficient coupling reactions for constructing complex heterocyclic scaffolds. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, particularly for developing novel active ingredients and fine chemicals. The CAS number for this product is 121772-94-9.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, especially kinase inhibitors and other nitrogen-containing heterocycles.
• Agrochemical Synthesis: Used in the research and development of advanced pesticides and herbicides, leveraging the pyridine core for bioactivity.
• Ligand and Catalyst Preparation: Serves as a precursor for creating specialized ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the development of functional organic materials, such as metal-organic frameworks (MOFs) or organic semiconductors.
• Fluorination Reagent: Acts as a source of the acyl fluoride moiety for introducing fluorocarbonyl groups into target molecules under mild conditions.
• Cross-Coupling Reactions: A valuable substrate in palladium-catalyzed cross-coupling reactions to form carbon-carbon bonds in complex molecules.

Basic Information

Product Name	3-Pyridinecarbonyl Fluoride, 6-Chloro- (9Ci)
CAS No.	121772-94-9
Molecular Formula	C6H3ClFNO
Molecular Weight	159.55 g/mol
Synonyms	6-Chloronicotinoyl Fluoride; 6-Chloropyridine-3-carbonyl Fluoride; 3-Carboxyfluoride-6-chloropyridine; 6-Chloro-3-pyridinecarbonyl fluoride; 6-Chloronicotinic acid fluoride; 6-Chloro-3-pyridoyl fluoride; 6-Chloro-3-fluorocarbonylpyridine; 2-Chloro-5-fluorocarbonylpyridine
EINECS	Contact for details

Quality Control

Our 3-Pyridinecarbonyl Fluoride, 6-Chloro- (9Ci) is manufactured under strict quality protocols to ensure batch-to-batch consistency and high purity for research and development applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing key parameters such as purity (by HPLC/NMR), identity confirmation, and impurity profiles. Our quality system is designed to meet the stringent requirements of advanced chemical synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and highly volatile nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition. Keep away from strong acids and organic solvents.

Specification

Item	Specification
Appearance	White to off-white crystalline solid or powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.