Description

2H-Thiopyran-4-Carbonyl Chloride, Tetrahydro- (9Ci) is a highly reactive organosulfur building block, specifically a cyclic thiopyran derivative activated as an acid chloride. This compound matters as a critical intermediate for introducing the tetrahydrothiopyran-4-carbonyl moiety into more complex molecular architectures, enabling the synthesis of novel pharmacophores and functional materials. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for constructing sulfur-containing heterocycles and targeted molecular scaffolds.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, infectious diseases, and metabolic conditions.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides that incorporate sulfur heterocycles for enhanced bioactivity.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the development of organic semiconductors, conductive polymers, and other advanced functional materials where the thiopyran ring system imparts specific electronic properties.
• Chemical Biology Probes: Useful for synthesizing activity-based probes and labeled compounds to study biological pathways and enzyme functions.
• Custom Synthesis and Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) producing bespoke compounds for client R&D programs.

Basic Information

Product Name	2H-Thiopyran-4-Carbonyl Chloride, Tetrahydro- (9Ci)
CAS No.	121654-84-0
Molecular Formula	C6H7ClOS
Molecular Weight	162.63 g/mol
Synonyms	Tetrahydro-2H-thiopyran-4-carbonyl chloride; 4-(Chlorocarbonyl)tetrahydro-2H-thiopyran; Tetrahydro-2H-thiopyran-4-carboxylic acid chloride; Perhydro-2H-thiopyran-4-carbonyl chloride; Thiacyclohexane-4-carbonyl chloride; 4-Carboxythiacyclohexane chloride; 121654-84-0 (CAS)
EINECS	Contact for details

Quality Control

Every batch of 2H-Thiopyran-4-Carbonyl Chloride, Tetrahydro- (9Ci) is produced and analyzed under strict quality management protocols to ensure consistency and reliability for sensitive synthetic applications. Our standard grade meets high-purity research specifications, with comprehensive identity and purity verification performed. Certificates of Analysis (COA) detailing batch-specific results are provided and available upon request. We support development toward cGMP standards for advanced pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature and reactivity as an acid chloride, the container must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening and protected from exposure to moisture and strong bases.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.