Description

3,4-Difluorophenylacetyl Chloride is a high-purity, reactive acyl chloride derivative, serving as a critical building block in advanced organic synthesis. Its value lies in enabling the efficient introduction of the 3,4-difluorophenylacetyl moiety, a privileged structural motif known for modulating the physicochemical and biological properties of target molecules. This intermediate is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for compounds targeting the central nervous system and metabolic disorders.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides, where the difluorophenyl group enhances bioavailability and stability.
• Liquid Crystal Materials: Acts as a building block for fluorinated liquid crystal compounds used in display technologies.
• Polymer Chemistry: Employed in the production of specialty polymers and functional materials requiring fluorinated aromatic units.
• Peptide Mimetics & Conjugates: Facilitates the acylation of amines in peptides or other biomolecules to create novel conjugates for drug discovery.
• Chemical Research & Development: Serves as a versatile reagent for academic and industrial R&D in medicinal and synthetic chemistry.

Basic Information

Product Name	3,4-Difluorophenylacetyl Chloride
CAS No.	121639-61-0
Molecular Formula	C8H5ClF2O
Molecular Weight	190.57 g/mol
Synonyms	2-(3,4-Difluorophenyl)acetyl Chloride; (3,4-Difluorophenyl)acetyl Chloride; 3,4-Difluorobenzeneacetyl Chloride; α-Chloro-3,4-difluoroacetophenone; 3,4-DFPAC; 2-(3,4-Difluorophenyl)ethanoyl Chloride; NSC 405124
EINECS	Contact for details

Quality Control

Our 3,4-Difluorophenylacetyl Chloride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your critical synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and reacts with strong acids/organic solvents; therefore, it must be kept under an inert atmosphere (e.g., nitrogen or argon) and away from moisture, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.