Description

1H-Pyrazole-4-Carbonylchloride,1-Methyl-5-Nitro-(9Ci) is a specialized heterocyclic building block of significant interest in advanced organic synthesis. This compound matters for its role as a key acyl chloride intermediate, enabling the efficient introduction of the 1-methyl-5-nitropyrazole moiety into complex molecular architectures. It is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, particularly those targeting specific biological pathways.

Application

• Pharmaceutical Intermediate: Critical for the synthesis of novel drug candidates, especially in medicinal chemistry programs targeting kinase inhibition or other enzyme modulation.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, leveraging the bioactive nitropyrazole scaffold.
• Chemical Biology: Serves as a versatile probe or linker precursor for bioconjugation and the study of protein-ligand interactions.
• Material Science: Potential building block for creating specialized polymers or ligands for catalytic systems with tailored properties.
• Custom Synthesis & Contract Manufacturing: A high-value intermediate for fine chemical suppliers serving the R&D and pilot-scale production needs of global clients.

Basic Information

Product Name	1H-Pyrazole-4-Carbonylchloride,1-Methyl-5-Nitro-(9Ci)
CAS No.	121568-18-1
Molecular Formula	C5H4ClN3O3
Molecular Weight	189.56 g/mol
Synonyms	1-Methyl-5-nitro-1H-pyrazole-4-carbonyl chloride; 1-Methyl-5-nitropyrazole-4-carbonyl chloride; 4-Carbonylchloride-1-methyl-5-nitro-1H-pyrazole; 1-Methyl-5-nitro-1H-pyrazole-4-carboxylic acid chloride; 1-Methyl-5-nitropyrazole-4-carboxylic acid chloride; (1-Methyl-5-nitro-1H-pyrazol-4-yl)carbonyl chloride
EINECS	Contact for details

Quality Control

Our production of 1H-Pyrazole-4-Carbonylchloride,1-Methyl-5-Nitro-(9Ci) adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. Each lot undergoes comprehensive analytical characterization, including HPLC, NMR, and IR spectroscopy. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Solubility	Soluble in common organic solvents (e.g., DCM, THF, DMF)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.