Description

Cyclohexanecarbonyl Chloride, 4-Cyano-, cis- (9Ci) is a high-purity, cis-configured organic intermediate featuring both a reactive acid chloride group and a cyano substituent. This compound is valued for its role as a key building block in the synthesis of complex, stereochemically defined molecules, particularly in advanced pharmaceutical research and fine chemical manufacturing. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing novel active compounds and functional materials.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of active pharmaceutical ingredients (APIs), especially those requiring a cis-substituted cyclohexane scaffold for specific biological activity.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides where the cyano and carbonyl chloride functionalities enable further derivatization.
• Ligand and Catalyst Development: Serves as a starting material for creating chiral ligands and organocatalysts used in asymmetric synthesis.
• Polymer Chemistry: Can be incorporated as a monomer or cross-linking agent to introduce cyclohexyl and cyano groups into polymer backbones, modifying thermal and mechanical properties.
• Fine Chemical Production: Employed in the multi-step synthesis of dyes, flavors, fragrances, and other high-value specialty chemicals.
• Academic and Industrial R&D: A valuable reagent for methodological studies in organic synthesis and for exploring new chemical spaces in drug discovery programs.

Basic Information

Product Name	Cyclohexanecarbonyl Chloride, 4-Cyano-, cis- (9Ci)
CAS No.	121487-73-8
Molecular Formula	C8H10ClNO
Molecular Weight	171.62 g/mol
Synonyms	cis-4-Cyanocyclohexanecarbonyl Chloride; (1r,4r)-4-Cyanocyclohexane-1-carbonyl Chloride; 4-Cyano-cis-cyclohexanecarbonyl Chloride; cis-4-Cyanocyclohexanoyl Chloride; 4-Cyanocyclohexanecarbonyl Chloride, cis-; 4-Cyano-cyclohexanecarboxylic Acid Chloride, cis-; (cis)-4-Cyanocyclohexanecarboxylic Acid Chloride
EINECS	Contact for details

Quality Control

Our Cyclohexanecarbonyl Chloride, 4-Cyano-, cis- (9Ci) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chromatographic purity assays and identity confirmation, to ensure it meets the stringent requirements of our clients in research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting key parameters such as assay purity, isomeric composition, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from moisture, strong bases, and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Isomeric Purity (cis-isomer)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.