Description

2,4(1H,3H)-Pyrimidinedione, 1-[2-Deoxy-2-Fluoro-5-o-[(4-Methoxyphenyl)Diphenylmethyl]-β-D-Arabinofuranosyl]-5-Methyl- is a sophisticated nucleoside analog building block of significant interest in advanced pharmaceutical research and development. This compound is a key protected intermediate in the synthesis of novel antiviral and anticancer agents, particularly those targeting viral polymerases. It is essential for medicinal chemists and process development scientists working in nucleoside chemistry and active pharmaceutical ingredient (API) synthesis. The precise control over its purity and stability is critical for ensuring the efficacy and safety of the final drug candidates.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel nucleoside-based antiviral drugs.
• Antiviral Agent Research: Used in the R&D of therapeutics targeting viruses such as hepatitis B (HBV), hepatitis C (HCV), and other viral infections.
• Oncology Drug Development: Serves as a precursor in the creation of nucleoside analogs with potential anticancer activity.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies to optimize drug potency and selectivity.
• Process Chemistry & Scale-up: Used in the development and optimization of scalable synthetic routes for API manufacturing.
• Biochemical Research: Acts as a substrate or inhibitor in enzymatic studies related to DNA/RNA synthesis and repair.

Basic Information

Product Name	2,4(1H,3H)-Pyrimidinedione, 1-[2-Deoxy-2-Fluoro-5-o-[(4-Methoxyphenyl)Diphenylmethyl]-β-D-Arabinofuranosyl]-5-Methyl-
CAS No.	121353-88-6
Molecular Formula	C30H29FN2O6
Molecular Weight	532.56 g/mol
Synonyms	1-((2R,3S,5R)-3-Fluoro-5-((4-methoxyphenyl)diphenylmethoxy)-2-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione; 5'-O-(4-Methoxytriphenylmethyl)-2'-fluoro-5-methyluridine; 2'-Fluoro-5-methyl-5'-O-MMTr-uridine; 2'-F-5-Me-5'-O-MMTr-U; 1-(2-Deoxy-2-fluoro-5-O-[(4-methoxyphenyl)diphenylmethyl]-β-D-arabinofuranosyl)-5-methyluracil; 2'-Fluoro-5-methyluridine 5'-O-MMTr ether; Protected 2'-Fluoro-5-methyluridine; MMTr-2'F-5MeU
EINECS	Contact for details

Quality Control

This high-value intermediate is produced under strict quality management systems to ensure batch-to-batch consistency and traceability. Quality is verified through a comprehensive suite of analytical techniques including HPLC for purity and impurity profiling, NMR for structural confirmation, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with each batch, documenting critical parameters such as assay, chiral purity, and levels of specific impurities. Our production adheres to cGMP guidelines where applicable, supporting its use in regulated pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment. For long-term storage, consider storing under an inert atmosphere to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Purity (HPLC, Area%)	≥ 98.5%
Single Maximum Impurity	≤ 0.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.