Description

3',3'-Difluoro-3'-Deoxythymidine is a fluorinated nucleoside analog of significant interest in advanced pharmaceutical research and development. This compound is valued for its role as a key synthetic intermediate and a potential active pharmaceutical ingredient (API) in the creation of novel antiviral and anticancer therapeutics. It is primarily utilized by research institutions, pharmaceutical manufacturers, and biotechnology companies engaged in nucleoside chemistry and drug discovery programs.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of novel antiviral and anticancer nucleoside analogs.
• Antiviral Research: Investigated for its potential activity against a range of viral targets, including HIV and hepatitis viruses.
• Oncology Research: Studied for its incorporation into DNA/RNA and potential mechanisms to inhibit tumor cell proliferation.
• Biochemical Tool: Used in enzymatic studies and as a probe to understand cellular metabolism and nucleic acid synthesis pathways.
• Process Chemistry: Serves as a starting material or intermediate in the scale-up and optimization of API manufacturing processes.
• Academic Research: Employed in university and institutional labs for fundamental studies in medicinal chemistry and chemical biology.

Basic Information

Product Name	3',3'-Difluoro-3'-Deoxythymidine
CAS No.	121353-87-5
Molecular Formula	C10H12F2N2O5
Molecular Weight	278.21 g/mol
Synonyms	3',3'-Difluoro-3'-deoxythymidine; 2'-Deoxy-3',3'-difluorothymidine; 3',3'-Difluorothymidine; 1-[(2R,4S,5R)-4-Fluoro-5-(fluoromethyl)tetrahydrofuran-2-yl]-5-methylpyrimidine-2,4(1H,3H)-dione; 3'-Fluoro-3'-deoxythymidine derivative; DFdT; FdT; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our 3',3'-Difluoro-3'-Deoxythymidine is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity, suitable for research and development applications. We provide comprehensive analytical data including HPLC purity, identity confirmation by spectroscopic methods (NMR, IR, MS), and residual solvent analysis. Certificates of Analysis (COA) documenting all critical quality attributes are available upon request to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.