Description

Pacidamycin 3 CAS NO 121280-49-7 is a specialized uridyl peptide antibiotic belonging to the pacidamycin family, a group of compounds known for their unique mechanism of action targeting bacterial cell wall biosynthesis. This compound is of significant interest in advanced pharmaceutical research and development due to its potent activity against Pseudomonas aeruginosa and other problematic Gram-negative pathogens. It serves as a critical reference standard and a key intermediate for researchers in antimicrobial discovery, medicinal chemistry, and biochemistry, particularly those focused on overcoming multidrug resistance.

Application

• Antimicrobial Research & Development: As a reference standard for studying novel antibiotic mechanisms of action and structure-activity relationships (SAR).
• Medicinal Chemistry: Used as a key intermediate or building block in the synthesis of new antibiotic analogs and derivatives.
• Biochemical Studies: Employed in enzymatic assays to investigate the inhibition of the bacterial translocase I (MraY) enzyme.
• Pharmaceutical Analysis: Serves as a high-purity analytical standard for quality control and method development in HPLC and LC-MS.
• Academic & Institutional Research: A vital tool for universities and research institutes exploring new solutions for antibiotic resistance.

Basic Information

Product Name	Pacidamycin 3
CAS No.	121280-49-7
Molecular Formula	C₃₄H₄₄N₁₀O₁₄
Molecular Weight	812.77 g/mol
Synonyms	Pacidamycin D; Antibiotic MJ 347-81F 3; Uridyl peptide antibiotic Pacidamycin 3; 5'-O-[(2S,3S)-3-[[(2S)-2-[[(2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-Acetamido-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-3-hydroxybutanoyl]amino]-3-methylpentanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-hydroxybutanoyl]uridine
EINECS	Contact for details

Quality Control

Every batch of Pacidamycin 3 is manufactured and analyzed under strict quality management protocols. Our products undergo rigorous identity, purity, and potency testing to ensure they meet the exacting standards required for pharmaceutical research. A comprehensive Certificate of Analysis (COA) detailing results for assay, related substances, residual solvents, and microbiological purity is provided with each shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, moisture-free environment. For long-term storage under inert atmosphere, it is recommended to seal the container under argon or nitrogen. Allow the product to equilibrate to room temperature before opening to minimize condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥95.0%
Water Content (KF)	≤5.0%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Meets ICH Q3C guidelines
Bacterial Endotoxins	<1.0 EU/mg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.