Description

3-(2,5-Dioxo-2,5-Dihydro-1H-Pyrrol-1-Yl)Propanoyl Chloride is a highly reactive acid chloride derivative of a pyrrolidine dione, serving as a critical building block for introducing a maleimide-reactive moiety into target molecules. Its primary value lies in enabling the synthesis of stable thioether linkages, which are essential for bioconjugation and polymer modification. This compound is particularly vital for researchers and manufacturers in the pharmaceutical, biotech, and advanced materials sectors who require precise and reliable conjugation chemistry.

Application

• Bioconjugation Reagent: Key intermediate for synthesizing antibody-drug conjugates (ADCs), protein-polymer conjugates, and peptide labeling agents via maleimide-thiol chemistry.
• Polymer Functionalization: Used to introduce reactive maleimide groups onto polymer backbones (e.g., PEG, PLGA) for creating smart drug delivery systems and functional biomaterials.
• Crosslinking Agent: Employed in the preparation of hydrogels, surface coatings, and crosslinked polymeric networks where controlled reactivity is required.
• Small Molecule Prodrug Synthesis: Facilitates the attachment of targeting ligands or solubilizing groups to active pharmaceutical ingredients (APIs).
• Surface Modification: Enables the covalent attachment of biomolecules (e.g., proteins, peptides) to nanoparticles, biosensors, and diagnostic assay platforms.
• Intermediate for Specialty Chemicals: Serves as a precursor for synthesizing more complex maleimide-containing compounds used in research and high-value chemical production.

Basic Information

Product Name	3-(2,5-Dioxo-2,5-Dihydro-1H-Pyrrol-1-Yl)Propanoyl Chloride
CAS No.	121215-45-0
Molecular Formula	C7H6ClNO3
Molecular Weight	187.58 g/mol
Synonyms	1-(3-Chloro-3-oxopropyl)-1H-pyrrole-2,5-dione; 3-(Maleimid-1-yl)propanoyl chloride; Maleimidopropionyl chloride; N-(3-Chlorocarbonylpropyl)maleimide; 3-Maleimidopropionic acid chloride; 1H-Pyrrole-2,5-dione, 1-(3-chloro-3-oxopropyl)-; 3-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)propionyl chloride
EINECS	Contact for details

Quality Control

Our production of 3-(2,5-Dioxo-2,5-Dihydro-1H-Pyrrol-1-Yl)Propanoyl Chloride adheres to stringent quality protocols to ensure batch-to-batch consistency and high reactivity. Each lot is characterized by multiple analytical techniques, including HPLC, NMR, and IR spectroscopy, to confirm identity, purity, and the absence of critical impurities like free acid or hydrolyzed product. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific customer or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) due to its moisture-sensitive and acid chloride nature. Keep away from strong bases, oxidizing agents, and sources of moisture. Allow the sealed container to reach ambient temperature before opening to minimize condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline solid or powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Free Acid (Titration)	≤ 1.0%
Solubility	Soluble in dichloromethane, THF, DMF; reacts with water and alcohols

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.