Description

N(2),3-Etheneodeoxyguanosine-5'-Triphosphate is a modified nucleoside triphosphate analog, a critical biochemical tool for studying DNA damage and repair mechanisms. Its primary value lies in its ability to act as a specific substrate or inhibitor in enzymatic assays, enabling precise research into mutagenesis and carcinogenesis. This compound is essential for researchers and developers in the fields of molecular biology, oncology research, and toxicology, where understanding DNA adduct formation is paramount.

Application

• Biochemical Research: Used as a specific substrate for DNA polymerases to study the incorporation of etheno-DNA adducts and their biological consequences.
• Mechanistic Toxicology: A key reagent in assays investigating the mechanisms of DNA damage induced by environmental carcinogens like vinyl chloride.
• Enzymology Studies: Employed to probe the activity, fidelity, and inhibition of DNA repair enzymes such as glycosylases that recognize and excise etheno adducts.
• Cancer Research: Facilitates the study of mutagenic pathways and the development of biomarkers for oxidative stress and lipid peroxidation-related DNA damage.
• Diagnostic Assay Development: Serves as a standard or critical component in the development of sensitive diagnostic kits for detecting specific DNA lesions.
• Pharmaceutical Screening: Used in high-throughput screening platforms to identify novel compounds that modulate DNA repair pathways.

Basic Information

Product Name	N(2),3-Etheneodeoxyguanosine-5'-Triphosphate
CAS No.	121055-54-7
Molecular Formula	C₁₂H₁₇N₅O₁₃P₃
Molecular Weight	580.21 g/mol
Synonyms	1,N²-Etheno-2'-deoxyguanosine-5'-triphosphate; εdGTP; 1,N²-Etheno-dGTP; 3,N²-Etheno-2'-deoxyguanosine-5'-triphosphate; Etheno-dGTP; 1,N²-ε-dGTP; 2'-Deoxy-1,N²-ethenoguanosine 5'-triphosphate; DNA Adduct dGTP Analog
EINECS	Contact for details

Quality Control

Our N(2),3-Etheneodeoxyguanosine-5'-Triphosphate is manufactured under stringent conditions to ensure the highest standards of purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot undergoes comprehensive analytical characterization, including HPLC purity analysis, NMR structural confirmation, and mass spectrometry verification. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, keep desiccated.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 3.0%
Solubility	Soluble in water or aqueous buffer

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.